PMC:7212965 / 96092-98142
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T235 | 192-195 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T236 | 318-323 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T237 | 535-545 | Body_part | denotes | flatulence | http://purl.org/sig/ont/fma/fma78440 |
| T238 | 579-584 | Body_part | denotes | Liver | http://purl.org/sig/ont/fma/fma7197 |
| T239 | 592-595 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T240 | 1173-1178 | Body_part | denotes | Liver | http://purl.org/sig/ont/fma/fma7197 |
| T241 | 1379-1384 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T242 | 1462-1467 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T243 | 1549-1554 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T244 | 1582-1587 | Body_part | denotes | urine | http://purl.org/sig/ont/fma/fma12274 |
| T245 | 1652-1657 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
| T246 | 2037-2042 | Body_part | denotes | liver | http://purl.org/sig/ont/fma/fma7197 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T194 | 318-323 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T195 | 579-584 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T196 | 1173-1178 | Body_part | denotes | Liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T197 | 1379-1384 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T198 | 1462-1467 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T199 | 1549-1554 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T200 | 1582-1587 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T201 | 1652-1657 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
| T202 | 2037-2042 | Body_part | denotes | liver | http://purl.obolibrary.org/obo/UBERON_0002107 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T457 | 100-108 | Disease | denotes | Diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T458 | 337-346 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T459 | 385-403 | Disease | denotes | hyperbilirubinemia | http://purl.obolibrary.org/obo/MONDO_0002408|http://purl.obolibrary.org/obo/MONDO_0024288 |
| T461 | 467-482 | Disease | denotes | hyperamylasemia | http://purl.obolibrary.org/obo/MONDO_0006789 |
| T462 | 492-501 | Disease | denotes | dyspepsia | http://purl.obolibrary.org/obo/MONDO_0002268 |
| T463 | 554-569 | Disease | denotes | gastroenteritis | http://purl.obolibrary.org/obo/MONDO_0002269 |
| T464 | 797-801 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T465 | 863-867 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T466 | 1190-1197 | Disease | denotes | Malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
| T467 | 1385-1391 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T468 | 1410-1413 | Disease | denotes | AIP | http://purl.obolibrary.org/obo/MONDO_0008294|http://purl.obolibrary.org/obo/MONDO_0015175|http://purl.obolibrary.org/obo/MONDO_0019203 |
| T471 | 1417-1420 | Disease | denotes | PCT | http://purl.obolibrary.org/obo/MONDO_0008296|http://purl.obolibrary.org/obo/MONDO_0015104 |
| T473 | 1658-1664 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T474 | 1715-1722 | Disease | denotes | Malaria | http://purl.obolibrary.org/obo/MONDO_0005136 |
| T475 | 1725-1728 | Disease | denotes | SLE | http://purl.obolibrary.org/obo/MONDO_0007915 |
| T476 | 1908-1924 | Disease | denotes | hypersensitivity | http://purl.obolibrary.org/obo/MONDO_0000605|http://purl.obolibrary.org/obo/MONDO_0005271 |
| T478 | 1966-1972 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T479 | 2043-2049 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T759 | 244-248 | http://purl.obolibrary.org/obo/CLO_0050509 | denotes | 2%–7 |
| T760 | 263-265 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T761 | 332-334 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T762 | 449-451 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T763 | 527-531 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 3%–5 |
| T764 | 579-584 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | Liver |
| T765 | 579-584 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | Liver |
| T766 | 639-641 | http://purl.obolibrary.org/obo/CLO_0007815 | denotes | mo |
| T767 | 781-783 | http://purl.obolibrary.org/obo/CLO_0009126 | denotes | SR |
| T768 | 832-834 | http://purl.obolibrary.org/obo/CLO_0009126 | denotes | SR |
| T769 | 1163-1168 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
| T770 | 1173-1178 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | Liver |
| T771 | 1173-1178 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | Liver |
| T772 | 1379-1384 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T773 | 1379-1384 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T774 | 1549-1554 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T775 | 1549-1554 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T776 | 1652-1657 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T777 | 1652-1657 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
| T778 | 1709-1714 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | label |
| T779 | 2037-2042 | http://purl.obolibrary.org/obo/UBERON_0002107 | denotes | liver |
| T780 | 2037-2042 | http://www.ebi.ac.uk/efo/EFO_0000887 | denotes | liver |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T291 | 45-47 | Chemical | denotes | GI | http://purl.obolibrary.org/obo/CHEBI_73907 |
| T292 | 143-152 | Chemical | denotes | Lopinavir | http://purl.obolibrary.org/obo/CHEBI_31781 |
| T293 | 153-162 | Chemical | denotes | ritonavir | http://purl.obolibrary.org/obo/CHEBI_45409 |
| T294 | 357-360 | Chemical | denotes | AST | http://purl.obolibrary.org/obo/CHEBI_76649 |
| T295 | 753-755 | Chemical | denotes | GI | http://purl.obolibrary.org/obo/CHEBI_73907 |
| T296 | 915-923 | Chemical | denotes | steroids | http://purl.obolibrary.org/obo/CHEBI_35341 |
| T297 | 998-1007 | Chemical | denotes | ribavirin | http://purl.obolibrary.org/obo/CHEBI_63580 |
| T298 | 1051-1060 | Chemical | denotes | ribavirin | http://purl.obolibrary.org/obo/CHEBI_63580 |
| T299 | 1072-1074 | Chemical | denotes | Al | http://purl.obolibrary.org/obo/CHEBI_28984 |
| T300 | 1131-1142 | Chemical | denotes | Chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T301 | 1163-1168 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T302 | 1410-1413 | Chemical | denotes | AIP | http://purl.obolibrary.org/obo/CHEBI_74006|http://purl.obolibrary.org/obo/CHEBI_74081 |
| T304 | 1709-1714 | Chemical | denotes | label | http://purl.obolibrary.org/obo/CHEBI_35209 |
| T305 | 1833-1844 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
| T306 | 1874-1885 | Chemical | denotes | chloroquine | http://purl.obolibrary.org/obo/CHEBI_3638 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T452 | 69-84 | Phenotype | denotes | Nausea/vomiting | http://purl.obolibrary.org/obo/HP_0002017 |
| T453 | 85-99 | Phenotype | denotes | Abdominal pain | http://purl.obolibrary.org/obo/HP_0002027 |
| T454 | 100-108 | Phenotype | denotes | Diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T455 | 109-117 | Phenotype | denotes | Jaundice | http://purl.obolibrary.org/obo/HP_0000952 |
| T456 | 196-202 | Phenotype | denotes | Nausea | http://purl.obolibrary.org/obo/HP_0002018 |
| T457 | 213-221 | Phenotype | denotes | vomiting | http://purl.obolibrary.org/obo/HP_0002013 |
| T458 | 337-346 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T459 | 385-403 | Phenotype | denotes | hyperbilirubinemia | http://purl.obolibrary.org/obo/HP_0002904 |
| T460 | 429-438 | Phenotype | denotes | Dysgeusia | http://purl.obolibrary.org/obo/HP_0031249 |
| T461 | 467-482 | Phenotype | denotes | hyperamylasemia | http://purl.obolibrary.org/obo/HP_0410288 |
| T462 | 492-501 | Phenotype | denotes | dyspepsia | http://purl.obolibrary.org/obo/HP_0410281 |
| T463 | 1230-1246 | Phenotype | denotes | Abdominal cramps | http://purl.obolibrary.org/obo/HP_0032155 |
| T464 | 1452-1457 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T465 | 1520-1528 | Phenotype | denotes | jaundice | http://purl.obolibrary.org/obo/HP_0000952 |
| T466 | 1725-1728 | Phenotype | denotes | SLE | http://purl.obolibrary.org/obo/HP_0002725 |
| T467 | 1908-1924 | Phenotype | denotes | hypersensitivity | http://purl.obolibrary.org/obo/HP_0041092 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T17 | 1535-1545 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T18 | 1908-1924 | http://purl.obolibrary.org/obo/GO_0002524 | denotes | hypersensitivity |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T971 | 0-68 | Sentence | denotes | Medication class Medication Sourcea Indirect GI adverse events Other |
| T972 | 69-132 | Sentence | denotes | Nausea/vomiting Abdominal pain Diarrhea Jaundice Hepatotoxicity |
| T973 | 133-328 | Sentence | denotes | Antiviral Lopinavir/ritonavir FDA/ manufacturer's label110 HIV Nausea (5%–16%); vomiting (children 21%; adults 2%–7%) Reported 1%–11% 7%–28%; greater with once-daily dosing — Increased serum ALT: |
| T974 | 329-380 | Sentence | denotes | 1%–11%; hepatitis including AST/ALT/GGT elevations: |
| T975 | 381-574 | Sentence | denotes | 4%; hyperbilirubinemia (children 3%; adults 1%) Dysgeusia (children 22%; adults <2%); hyperamylasemia (3%–8%), dyspepsia (<6%), increased lipase (3%–5%), flatulence (1-4%), gastroenteritis (3%) |
| T976 | 575-619 | Sentence | denotes | NIH Liver Tox111 HIV Range from mild to ALF. |
| T977 | 620-642 | Sentence | denotes | Recovery takes 1–2 mo. |
| T978 | 643-679 | Sentence | denotes | Do not re-challenge with medication. |
| T979 | 680-715 | Sentence | denotes | Monitor for exacerbation of HBV/HCV |
| T980 | 716-783 | Sentence | denotes | Momattin,105 2019 MERS Prevalence of GI AEs not reported in this SR |
| T981 | 784-868 | Sentence | denotes | Yao,106 2020 SARS/MERS AEs not reported in this SR (can check primary studies) SARS: |
| T982 | 869-931 | Sentence | denotes | 2 retrospective cohort studies (combined with steroids); MERS: |
| T983 | 932-1060 | Sentence | denotes | 1 RCT combined with IFN, 1 retrospective cohort combined with IFN/ribavirin, and 2 case reports also combined with IFN/ribavirin |
| T984 | 1061-1095 | Sentence | denotes | Remdesivir Al-Tawfiq,107 2020 MERS |
| T985 | 1096-1117 | Sentence | denotes | Sheahan,108 2020 MERS |
| T986 | 1118-1392 | Sentence | denotes | Antimalarial Chloroquine FDA/ manufacturer's label/NIH Liver Tox111,112 Malaria Reported; frequency not defined Abdominal cramps reported; frequency not defined Reported; frequency not defined Rarely linked to aminotransferase elevations or clinically apparent liver injury. |
| T987 | 1393-1605 | Sentence | denotes | In patients with AIP or PCT, it can trigger an attack with fever and serum aminotransferase elevations, sometimes resulting in jaundice Minor metabolism by liver (∼30%); mostly excreted in urine Likelihood score: |
| T988 | 1606-1665 | Sentence | denotes | D (possible rare cause of clinically apparent liver injury) |
| T989 | 1666-1990 | Sentence | denotes | Hydroxychloroquine113 FDA / Manufacturer's label Malaria / SLE Reported; frequency not defined Reported; frequency not defined Reported; frequency not defined Same as chloroquine above; can be exchanged with chloroquine as most reactions are hypersensitivity and no known cross reactivity to hepatic injury Likelihood score: |
| T990 | 1991-2050 | Sentence | denotes | D (possible rare cause of clinically apparent liver injury) |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2572 | 365-368 | Gene | denotes | GGT | Gene:653590 |
| 2573 | 615-618 | Gene | denotes | ALF | Gene:11036 |
| 2574 | 753-755 | Gene | denotes | GI | Gene:2770 |
| 2575 | 45-47 | Gene | denotes | GI | Gene:2770 |
| 2576 | 223-231 | Species | denotes | children | Tax:9606 |
| 2577 | 405-413 | Species | denotes | children | Tax:9606 |
| 2578 | 440-448 | Species | denotes | children | Tax:9606 |
| 2579 | 1396-1404 | Species | denotes | patients | Tax:9606 |
| 2580 | 143-162 | Chemical | denotes | Lopinavir/ritonavir | MESH:C558899 |
| 2581 | 1061-1071 | Chemical | denotes | Remdesivir | MESH:C000606551 |
| 2582 | 69-75 | Disease | denotes | Nausea | MESH:D009325 |
| 2583 | 76-132 | Disease | denotes | vomiting Abdominal pain Diarrhea Jaundice Hepatotoxicity | MESH:D015746 |
| 2584 | 168-202 | Disease | denotes | manufacturer's label110 HIV Nausea | MESH:D009325 |
| 2585 | 213-221 | Disease | denotes | vomiting | MESH:D014839 |
| 2586 | 337-346 | Disease | denotes | hepatitis | MESH:D056486 |
| 2587 | 385-403 | Disease | denotes | hyperbilirubinemia | MESH:D006932 |
| 2588 | 429-438 | Disease | denotes | Dysgeusia | MESH:D004408 |
| 2589 | 467-482 | Disease | denotes | hyperamylasemia | MESH:D034321 |
| 2590 | 492-501 | Disease | denotes | dyspepsia | MESH:D004415 |
| 2591 | 535-545 | Disease | denotes | flatulence | MESH:D005414 |
| 2592 | 554-569 | Disease | denotes | gastroenteritis | MESH:D005759 |
| 2593 | 575-595 | Disease | denotes | NIH Liver Tox111 HIV | MESH:D017093 |
| 2594 | 734-738 | Disease | denotes | MERS | MESH:D018352 |
| 2595 | 802-806 | Disease | denotes | MERS | MESH:D018352 |
| 2596 | 926-930 | Disease | denotes | MERS | MESH:D018352 |
| 2597 | 1091-1095 | Disease | denotes | MERS | MESH:D018352 |
| 2598 | 1113-1117 | Disease | denotes | MERS | MESH:D018352 |
| 2599 | 1169-1197 | Disease | denotes | NIH Liver Tox111,112 Malaria | MESH:D008288 |
| 2600 | 1379-1391 | Disease | denotes | liver injury | MESH:D017093 |
| 2601 | 1410-1413 | Disease | denotes | AIP | MESH:D017118 |
| 2602 | 1452-1457 | Disease | denotes | fever | MESH:D005334 |
| 2603 | 1520-1528 | Disease | denotes | jaundice | MESH:D007565 |
| 2604 | 1652-1664 | Disease | denotes | liver injury | MESH:D017093 |
| 2605 | 1694-1722 | Disease | denotes | Manufacturer's label Malaria | MESH:D008288 |
| 2606 | 1725-1728 | Disease | denotes | SLE | MESH:D008180 |
| 2607 | 1908-1924 | Disease | denotes | hypersensitivity | MESH:D004342 |
| 2608 | 1958-1972 | Disease | denotes | hepatic injury | MESH:D056486 |
| 2609 | 2037-2049 | Disease | denotes | liver injury | MESH:D017093 |