PMC:7212965 / 12964-13661 JSONTXT

{"project":"2_test","denotations":[{"id":"32407808-23517554-43469241","span":{"begin":695,"end":697},"obj":"23517554"}],"text":"Certainty of Evidence\nCertainty of evidence was evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework. The certainty of evidence was categorized into 4 levels ranging from very low to high. Within the GRADE framework, evidence from randomized controlled trials (RCTs) starts as high-certainty evidence and observational studies start out as low-certainty evidence, but can be rated down for the following reasons: risk of bias, inconsistency, indirectness, imprecision, and publication bias. Additionally, evidence from well-conducted observational studies start as low-certainty evidence, but can be rated up for large effects or dose–response.14"}

{"project":"LitCovid-sentences","denotations":[{"id":"T96","span":{"begin":0,"end":21},"obj":"Sentence"},{"id":"T97","span":{"begin":22,"end":152},"obj":"Sentence"},{"id":"T98","span":{"begin":153,"end":239},"obj":"Sentence"},{"id":"T99","span":{"begin":240,"end":541},"obj":"Sentence"},{"id":"T100","span":{"begin":542,"end":697},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Certainty of Evidence\nCertainty of evidence was evaluated using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) framework. The certainty of evidence was categorized into 4 levels ranging from very low to high. Within the GRADE framework, evidence from randomized controlled trials (RCTs) starts as high-certainty evidence and observational studies start out as low-certainty evidence, but can be rated down for the following reasons: risk of bias, inconsistency, indirectness, imprecision, and publication bias. Additionally, evidence from well-conducted observational studies start as low-certainty evidence, but can be rated up for large effects or dose–response.14"}