MERS
Study Alserehi et al (2016)N = 1, confirmed case (32 weeks)Case report Assiri et al (2016)N = 5, confirmed cases (all ≥22 weeks)Case series, retrospective Jeong et al (2017)N = 1, confirmed caseCase report, review Alfaraj et al (2019)N = 2, confirmed cases (6 weeks and 24 weeks)Case report, review
Clinical features Healthy infant at 32 weeks via C-section • All required ICU
• 1 stillbirth, 1 neonatal death
• 2 patients died • Asymptomatic patient
• Healthy infant at 37 weeks via C-section due to placental abruption • Asymptomatic patients
• ICU care (54%)
• Death (27%) (1 infected in second trimester, 2 in third)
• Infant death rate: 27%
• Case fatality rate: 35% (similar to nonpregnant, P = 0.75)
Key findings on investigations Infant negative for MERS-CoV N/A No neonatal IgG N/A
Key study findings and message Younger age, infection in later gestational period and immune response may contribute to successful outcome Infection may be associated with maternal and perinatal death and disease Healthy mother and infant, benign course Case fatality similar to nonpregnant cases