MERS
Study Assiri et al (2013)N = 47, confirmed casesRetrospective study Arabi et al (2014)N = 12, (11 confirmed cases, 1 probable)Case series Al-Abdley et al (2019)N = 33, confirmed casesRetrospective study Almekhlafi et al (2016)N = 31, confirmed casesRetrospective study
Clinical features • Preexisting chronic lung disease (26%)
• Smokers (23%)
• Fever (98%)
• Cough (83%)
• Dry (47%)
• Productive (36%)
• Dyspnea (72%)
• Sore throat (21%)
• Rhinorrhea (4%) • Preexisting chronic lung disease (8%)
• Dyspnea (92%)
• Cough (83%)
• Fever (67%)
• Wheezing (17%)
• Productive cough (17%)
• Rhinorrhea (8%)
• Hemoptysis (8%)
• Sore throat (8%) • Preexisting chronic lung disease (12%)
• Fever (75.7%)
• Cough (72%)
• Dyspnea (59%)
• Sore throat (12%)
Rhinorrhea (9%) • Cough (100%)
• Tachypnea (100%)
• Fever (87.1%)
• Sore throat (25.8%)
• Crackles (93.5 %)
Rhonchi (32.3 %)
Key findings on investigations CXR abnormality (100%) – ARDS pattern CXR, CT: lobular to bilateral extensive ARDS pattern N/A CXR abnormality (96.4%)
Key study findings and message • 89% ICU admission
• 72% mechanical ventilation
• 60% case fatality rate 100% invasive mechanical ventilation, mean duration 100 days • Dyspnea before admission was associated with a more severe outcome (P < 0.001)
Prolonged MERS-CoV detection in URT in diabetics (P = 0.049) • 87.1 % invasive mechanical ventilation (87.1%)
• 74.2% overall ICU mortality rate
• Mortality in ICU associated with older age, severe disease and organ failure.