Qiu and Shi acknowledge the support from the 111 Project of China (Grant No.B18026). Chen thanks the following funding sources: US PEPPER Center Scholar Award (P30AG021342) and NIH/NIA grants (R03AG048920; K01AG053408). Shi thanks the National Natural Science Foundation of China (Grant No.71803062) and the Ministry of Education of China (Grant No.18YJC790138) for financial support.