Health facilities in Wuhan had been extremely overstretched with shortage in medical supplies and high rates of nosocomial infections until February 2 when (1) two new hospitals, i.e., Huoshenshan and Leishenshan, were built to treat patients of COVID-19 with severe symptoms, and (2) 14 makeshift health facilities were converted to isolate patients with mild symptoms and to quarantine people suspected of contracting COVID-19, patients with fever symptoms, and close contacts of confirmed patients. This centralized treatment and isolation strategy since February 2 has substantially reduced transmission and incident cases.