PMC:7205724 / 7216-7826
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
266 | 58-62 | Gene | denotes | ACE2 | Gene:59272 |
267 | 138-142 | Gene | denotes | ACE2 | Gene:59272 |
268 | 17-25 | Species | denotes | SARS-CoV | Tax:694009 |
269 | 52-57 | Species | denotes | human | Tax:9606 |
270 | 70-80 | Species | denotes | SARS-CoV 2 | Tax:2697049 |
271 | 132-137 | Species | denotes | human | Tax:9606 |
272 | 346-354 | Species | denotes | SARS-CoV | Tax:694009 |
273 | 596-606 | Species | denotes | SARS-CoV 2 | Tax:2697049 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T49 | 17-25 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T50 | 70-78 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T51 | 346-354 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T52 | 596-604 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T82 | 52-57 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T83 | 91-92 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T84 | 132-137 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
T85 | 246-249 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T65 | 17-25 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T66 | 52-57 | Species | denotes | human | NCBItxid:9606 |
T67 | 70-80 | Species | denotes | SARS-CoV 2 | NCBItxid:2697049 |
T68 | 132-137 | Species | denotes | human | NCBItxid:9606 |
T69 | 346-354 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T70 | 596-606 | Species | denotes | SARS-CoV 2 | NCBItxid:2697049 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T66 | 0-225 | Sentence | denotes | When compared to SARS-CoV SB, the motif binding the human ACE2 to the SARS-CoV 2 SB showed a relatively higher binding affinity for human ACE2 as indicated in smaller equilibrium dissociation constant (2.9 nM vs. 7.7 nM) [3]. |
T67 | 226-610 | Sentence | denotes | Structural analysis has demonstrated that fourteen positions critically take part in the receptor-binding domain of the SARS-CoV SB that contain eight conserved (T402, Y436, Y440, N473, Y475, T486, G488, and Y491) positions and six semi-conserved (R426 to N448, Y442 to L464, L472 to F495, N479 to Q502, Y484 to Q507, and T487 to N510) substitutions with respect to the SARS-CoV 2 SB. |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
268 | 17-25 | Species | denotes | SARS-CoV | Tax:694009 |
269 | 52-57 | Species | denotes | human | Tax:9606 |
266 | 58-62 | Gene | denotes | ACE2 | Gene:59272 |
270 | 70-80 | Species | denotes | SARS-CoV 2 | Tax:2697049 |
271 | 132-137 | Species | denotes | human | Tax:9606 |
267 | 138-142 | Gene | denotes | ACE2 | Gene:59272 |
272 | 346-354 | Species | denotes | SARS-CoV | Tax:694009 |
273 | 596-606 | Species | denotes | SARS-CoV 2 | Tax:2697049 |
LitCovid-sample-Enju
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1199 | 0-4 | WRB | denotes | When |
T1200 | 5-13 | VBN | denotes | compared |
T1201 | 14-16 | TO | denotes | to |
T1202 | 17-25 | NNP | denotes | SARS-CoV |
T1203 | 26-28 | NNP | denotes | SB |
T1204 | 28-29 | -COMMA- | denotes | , |
T1205 | 30-33 | DT | denotes | the |
T1206 | 34-39 | NN | denotes | motif |
T1207 | 40-47 | VBG | denotes | binding |
T1208 | 48-51 | DT | denotes | the |
T1209 | 52-57 | JJ | denotes | human |
T1210 | 58-62 | NN | denotes | ACE2 |
T1211 | 63-65 | TO | denotes | to |
T1212 | 66-69 | DT | denotes | the |
T1213 | 70-78 | JJ | denotes | SARS-CoV |
T1214 | 79-80 | CD | denotes | 2 |
T1215 | 81-83 | NN | denotes | SB |
T1216 | 84-90 | VBD | denotes | showed |
T1217 | 91-92 | DT | denotes | a |
T1218 | 93-103 | RB | denotes | relatively |
T1219 | 104-110 | JJR | denotes | higher |
T1220 | 111-118 | NN | denotes | binding |
T1221 | 119-127 | NN | denotes | affinity |
T1222 | 128-131 | IN | denotes | for |
T1223 | 132-137 | JJ | denotes | human |
T1224 | 138-142 | NN | denotes | ACE2 |
T1225 | 143-145 | IN | denotes | as |
T1226 | 146-155 | VBN | denotes | indicated |
T1227 | 156-158 | IN | denotes | in |
T1228 | 159-166 | JJR | denotes | smaller |
T1229 | 167-178 | NN | denotes | equilibrium |
T1230 | 179-191 | NN | denotes | dissociation |
T1231 | 192-200 | NN | denotes | constant |
T1232 | 201-202 | -LRB- | denotes | ( |
T1233 | 202-208 | NN | denotes | 2.9 nM |
T1234 | 209-212 | IN | denotes | vs. |
T1235 | 213-219 | NN | denotes | 7.7 nM |
T1236 | 219-220 | -RRB- | denotes | ) |
T1237 | 221-222 | -LRB- | denotes | [ |
T1238 | 222-223 | CD | denotes | 3 |
T1239 | 223-224 | -RRB- | denotes | ] |
T1240 | 226-236 | JJ | denotes | Structural |
T1241 | 237-245 | NN | denotes | analysis |
T1242 | 246-249 | VBZ | denotes | has |
T1243 | 250-262 | VBN | denotes | demonstrated |
T1244 | 263-267 | IN | denotes | that |
T1245 | 268-276 | CD | denotes | fourteen |
T1246 | 277-286 | NNS | denotes | positions |
T1247 | 287-297 | RB | denotes | critically |
T1248 | 298-302 | VBP | denotes | take |
T1249 | 303-307 | NN | denotes | part |
T1250 | 308-310 | IN | denotes | in |
T1251 | 311-314 | DT | denotes | the |
T1252 | 315-331 | JJ | denotes | receptor-binding |
T1253 | 332-338 | NN | denotes | domain |
T1254 | 339-341 | IN | denotes | of |
T1255 | 342-345 | DT | denotes | the |
T1256 | 346-354 | NN | denotes | SARS-CoV |
T1257 | 355-357 | NN | denotes | SB |
T1258 | 358-362 | WDT | denotes | that |
T1259 | 363-370 | VBP | denotes | contain |
T1260 | 371-376 | CD | denotes | eight |
T1261 | 377-386 | VBN | denotes | conserved |
T1262 | 387-388 | -LRB- | denotes | ( |
T1263 | 388-392 | NN | denotes | T402 |
T1264 | 392-393 | -COMMA- | denotes | , |
T1265 | 394-398 | NN | denotes | Y436 |
T1266 | 398-399 | -COMMA- | denotes | , |
T1267 | 400-404 | NN | denotes | Y440 |
T1268 | 404-405 | -COMMA- | denotes | , |
T1269 | 406-410 | NN | denotes | N473 |
T1270 | 410-411 | -COMMA- | denotes | , |
T1271 | 412-416 | NN | denotes | Y475 |
T1272 | 416-417 | -COMMA- | denotes | , |
T1273 | 418-422 | NN | denotes | T486 |
T1274 | 422-423 | -COMMA- | denotes | , |
T1275 | 424-428 | NN | denotes | G488 |
T1276 | 428-429 | -COMMA- | denotes | , |
T1277 | 430-433 | CC | denotes | and |
T1278 | 434-438 | NN | denotes | Y491 |
T1279 | 438-439 | -RRB- | denotes | ) |
T1280 | 440-449 | NNS | denotes | positions |
T1281 | 450-453 | CC | denotes | and |
T1282 | 454-457 | CD | denotes | six |
T1283 | 458-472 | JJ | denotes | semi-conserved |
T1284 | 473-474 | -LRB- | denotes | ( |
T1285 | 474-478 | NN | denotes | R426 |
T1286 | 479-481 | TO | denotes | to |
T1287 | 482-486 | NN | denotes | N448 |
T1288 | 486-487 | -COMMA- | denotes | , |
T1289 | 488-492 | NN | denotes | Y442 |
T1290 | 493-495 | TO | denotes | to |
T1291 | 496-500 | NN | denotes | L464 |
T1292 | 500-501 | -COMMA- | denotes | , |
T1293 | 502-506 | NN | denotes | L472 |
T1294 | 507-509 | TO | denotes | to |
T1295 | 510-514 | NN | denotes | F495 |
T1296 | 514-515 | -COMMA- | denotes | , |
T1297 | 516-520 | NN | denotes | N479 |
T1298 | 521-523 | TO | denotes | to |
T1299 | 524-528 | NN | denotes | Q502 |
T1300 | 528-529 | -COMMA- | denotes | , |
T1301 | 530-534 | NN | denotes | Y484 |
T1302 | 535-537 | TO | denotes | to |
T1303 | 538-542 | NN | denotes | Q507 |
T1304 | 542-543 | -COMMA- | denotes | , |
T1305 | 544-547 | CC | denotes | and |
T1306 | 548-552 | NN | denotes | T487 |
T1307 | 553-555 | TO | denotes | to |
T1308 | 556-560 | NN | denotes | N510 |
T1309 | 560-561 | -RRB- | denotes | ) |
T1310 | 562-575 | NNS | denotes | substitutions |
T1311 | 576-580 | IN | denotes | with |
T1312 | 581-588 | NN | denotes | respect |
T1313 | 589-591 | TO | denotes | to |
T1314 | 592-595 | DT | denotes | the |
T1315 | 596-604 | JJ | denotes | SARS-CoV |
T1316 | 605-606 | CD | denotes | 2 |
T1317 | 607-609 | NN | denotes | SB |
R1203 | T1215 | T1212 | arg1Of | SB,the |
R1204 | T1215 | T1213 | arg1Of | SB,SARS-CoV |
R1205 | T1215 | T1214 | arg1Of | SB,2 |
R1206 | T1206 | T1216 | arg1Of | motif,showed |
R1293 | T1301 | T1300 | arg2Of | Y484,"," |
R1294 | T1301 | T1302 | arg1Of | Y484,to |
R1295 | T1303 | T1302 | arg2Of | Q507,to |
R1296 | T1305 | T1304 | arg1Of | and,"," |
R1190 | T1216 | T1199 | arg1Of | showed,When |
R1191 | T1200 | T1199 | arg2Of | compared,When |
R1192 | T1200 | T1201 | arg1Of | compared,to |
R1193 | T1203 | T1201 | arg2Of | SB,to |
R1194 | T1203 | T1202 | arg1Of | SB,SARS-CoV |
R1195 | T1216 | T1204 | arg1Of | showed,"," |
R1196 | T1206 | T1205 | arg1Of | motif,the |
R1197 | T1206 | T1207 | arg1Of | motif,binding |
R1198 | T1210 | T1207 | arg2Of | ACE2,binding |
R1199 | T1210 | T1208 | arg1Of | ACE2,the |
R1200 | T1210 | T1209 | arg1Of | ACE2,human |
R1201 | T1210 | T1211 | arg1Of | ACE2,to |
R1202 | T1215 | T1211 | arg2Of | SB,to |
R1207 | T1221 | T1216 | arg2Of | affinity,showed |
R1208 | T1225 | T1216 | arg3Of | as,showed |
R1209 | T1221 | T1217 | arg1Of | affinity,a |
R1210 | T1219 | T1218 | arg1Of | higher,relatively |
R1211 | T1221 | T1219 | arg1Of | affinity,higher |
R1212 | T1221 | T1220 | arg1Of | affinity,binding |
R1213 | T1221 | T1222 | arg1Of | affinity,for |
R1214 | T1224 | T1222 | arg2Of | ACE2,for |
R1215 | T1224 | T1223 | arg1Of | ACE2,human |
R1216 | T1226 | T1225 | arg2Of | indicated,as |
R1217 | T1226 | T1227 | arg1Of | indicated,in |
R1218 | T1231 | T1227 | arg2Of | constant,in |
R1219 | T1231 | T1228 | arg1Of | constant,smaller |
R1220 | T1231 | T1229 | arg1Of | constant,equilibrium |
R1221 | T1231 | T1230 | arg1Of | constant,dissociation |
R1222 | T1231 | T1232 | arg1Of | constant,( |
R1223 | T1233 | T1232 | arg2Of | 2.9 nM,( |
R1224 | T1236 | T1232 | arg3Of | ),( |
R1225 | T1233 | T1234 | arg1Of | 2.9 nM,vs. |
R1226 | T1235 | T1234 | arg2Of | 7.7 nM,vs. |
R1227 | T1216 | T1237 | arg1Of | showed,[ |
R1228 | T1238 | T1237 | arg2Of | 3,[ |
R1229 | T1239 | T1237 | arg3Of | ],[ |
R1230 | T1241 | T1240 | arg1Of | analysis,Structural |
R1231 | T1241 | T1242 | arg1Of | analysis,has |
R1232 | T1243 | T1242 | arg2Of | demonstrated,has |
R1233 | T1241 | T1243 | arg1Of | analysis,demonstrated |
R1234 | T1248 | T1243 | arg2Of | take,demonstrated |
R1235 | T1248 | T1244 | arg1Of | take,that |
R1236 | T1246 | T1245 | arg1Of | positions,fourteen |
R1237 | T1248 | T1247 | arg1Of | take,critically |
R1238 | T1246 | T1248 | arg1Of | positions,take |
R1239 | T1249 | T1248 | arg2Of | part,take |
R1240 | T1248 | T1250 | arg1Of | take,in |
R1241 | T1253 | T1250 | arg2Of | domain,in |
R1242 | T1253 | T1251 | arg1Of | domain,the |
R1243 | T1253 | T1252 | arg1Of | domain,receptor-binding |
R1244 | T1253 | T1254 | arg1Of | domain,of |
R1245 | T1257 | T1254 | arg2Of | SB,of |
R1246 | T1257 | T1255 | arg1Of | SB,the |
R1247 | T1257 | T1256 | arg1Of | SB,SARS-CoV |
R1248 | T1257 | T1258 | arg1Of | SB,that |
R1249 | T1257 | T1259 | arg1Of | SB,contain |
R1250 | T1281 | T1259 | arg2Of | and,contain |
R1251 | T1281 | T1260 | arg1Of | and,eight |
R1252 | T1281 | T1261 | arg1Of | and,conserved |
R1253 | T1280 | T1262 | arg1Of | positions,( |
R1254 | T1277 | T1262 | arg2Of | and,( |
R1255 | T1279 | T1262 | arg3Of | ),( |
R1256 | T1263 | T1264 | arg1Of | T402,"," |
R1257 | T1265 | T1264 | arg2Of | Y436,"," |
R1258 | T1264 | T1266 | arg1Of | ",","," |
R1259 | T1267 | T1266 | arg2Of | Y440,"," |
R1260 | T1266 | T1268 | arg1Of | ",","," |
R1261 | T1269 | T1268 | arg2Of | N473,"," |
R1262 | T1268 | T1270 | arg1Of | ",","," |
R1263 | T1271 | T1270 | arg2Of | Y475,"," |
R1264 | T1270 | T1272 | arg1Of | ",","," |
R1265 | T1273 | T1272 | arg2Of | T486,"," |
R1266 | T1272 | T1274 | arg1Of | ",","," |
R1267 | T1275 | T1274 | arg2Of | G488,"," |
R1268 | T1277 | T1276 | arg1Of | and,"," |
R1269 | T1274 | T1277 | arg1Of | ",",and |
R1270 | T1278 | T1277 | arg2Of | Y491,and |
R1271 | T1280 | T1281 | arg1Of | positions,and |
R1272 | T1310 | T1281 | arg2Of | substitutions,and |
R1273 | T1283 | T1282 | arg1Of | semi-conserved,six |
R1274 | T1310 | T1283 | arg1Of | substitutions,semi-conserved |
R1275 | T1283 | T1284 | arg1Of | semi-conserved,( |
R1276 | T1296 | T1284 | arg2Of | ",",( |
R1277 | T1309 | T1284 | arg3Of | ),( |
R1278 | T1285 | T1286 | arg1Of | R426,to |
R1279 | T1287 | T1286 | arg2Of | N448,to |
R1280 | T1287 | T1288 | arg1Of | N448,"," |
R1281 | T1289 | T1288 | arg2Of | Y442,"," |
R1282 | T1289 | T1290 | arg1Of | Y442,to |
R1283 | T1291 | T1290 | arg2Of | L464,to |
R1284 | T1287 | T1292 | arg1Of | N448,"," |
R1285 | T1293 | T1292 | arg2Of | L472,"," |
R1286 | T1293 | T1294 | arg1Of | L472,to |
R1287 | T1295 | T1294 | arg2Of | F495,to |
R1288 | T1285 | T1296 | arg1Of | R426,"," |
R1289 | T1305 | T1296 | arg2Of | and,"," |
R1290 | T1297 | T1298 | arg1Of | N479,to |
R1291 | T1299 | T1298 | arg2Of | Q502,to |
R1292 | T1299 | T1300 | arg1Of | Q502,"," |
R1297 | T1297 | T1305 | arg1Of | N479,and |
R1298 | T1306 | T1305 | arg2Of | T487,and |
R1299 | T1305 | T1307 | arg1Of | and,to |
R1300 | T1308 | T1307 | arg2Of | N510,to |
R1301 | T1259 | T1311 | arg1Of | contain,with |
R1302 | T1312 | T1311 | arg2Of | respect,with |
R1303 | T1317 | T1311 | arg3Of | SB,with |
R1304 | T1311 | T1313 | arg1Of | with,to |
R1305 | T1317 | T1314 | arg1Of | SB,the |
R1306 | T1317 | T1315 | arg1Of | SB,SARS-CoV |
R1307 | T1317 | T1316 | arg1Of | SB,2 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T48 | 17-25 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T49 | 70-80 | Disease | denotes | SARS-CoV 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T50 | 346-354 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T51 | 596-606 | Disease | denotes | SARS-CoV 2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T66 | 0-225 | Sentence | denotes | When compared to SARS-CoV SB, the motif binding the human ACE2 to the SARS-CoV 2 SB showed a relatively higher binding affinity for human ACE2 as indicated in smaller equilibrium dissociation constant (2.9 nM vs. 7.7 nM) [3]. |
T67 | 226-610 | Sentence | denotes | Structural analysis has demonstrated that fourteen positions critically take part in the receptor-binding domain of the SARS-CoV SB that contain eight conserved (T402, Y436, Y440, N473, Y475, T486, G488, and Y491) positions and six semi-conserved (R426 to N448, Y442 to L464, L472 to F495, N479 to Q502, Y484 to Q507, and T487 to N510) substitutions with respect to the SARS-CoV 2 SB. |