PMC:7205724 / 26104-26941 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"920","span":{"begin":23,"end":27},"obj":"Gene"},{"id":"921","span":{"begin":32,"end":38},"obj":"Chemical"},{"id":"935","span":{"begin":70,"end":99},"obj":"Gene"},{"id":"936","span":{"begin":101,"end":104},"obj":"Gene"},{"id":"937","span":{"begin":238,"end":242},"obj":"Gene"},{"id":"938","span":{"begin":244,"end":254},"obj":"Gene"},{"id":"939","span":{"begin":256,"end":262},"obj":"Gene"},{"id":"940","span":{"begin":268,"end":273},"obj":"Gene"},{"id":"941","span":{"begin":471,"end":477},"obj":"Gene"},{"id":"942","span":{"begin":482,"end":488},"obj":"Gene"},{"id":"943","span":{"begin":198,"end":202},"obj":"Species"},{"id":"944","span":{"begin":185,"end":197},"obj":"Disease"},{"id":"945","span":{"begin":306,"end":317},"obj":"Disease"},{"id":"946","span":{"begin":332,"end":344},"obj":"Disease"},{"id":"947","span":{"begin":539,"end":560},"obj":"Disease"},{"id":"953","span":{"begin":768,"end":773},"obj":"Species"},{"id":"954","span":{"begin":562,"end":568},"obj":"Chemical"},{"id":"955","span":{"begin":644,"end":650},"obj":"Chemical"},{"id":"956","span":{"begin":825,"end":831},"obj":"Chemical"},{"id":"957","span":{"begin":608,"end":624},"obj":"Disease"}],"attributes":[{"id":"A920","pred":"tao:has_database_id","subj":"920","obj":"Gene:59272"},{"id":"A921","pred":"tao:has_database_id","subj":"921","obj":"MESH:D003300"},{"id":"A935","pred":"tao:has_database_id","subj":"935","obj":"Gene:24310"},{"id":"A936","pred":"tao:has_database_id","subj":"936","obj":"Gene:24310"},{"id":"A937","pred":"tao:has_database_id","subj":"937","obj":"Gene:59272"},{"id":"A938","pred":"tao:has_database_id","subj":"938","obj":"Gene:999"},{"id":"A939","pred":"tao:has_database_id","subj":"939","obj":"Gene:5243"},{"id":"A940","pred":"tao:has_database_id","subj":"940","obj":"Gene:3394"},{"id":"A941","pred":"tao:has_database_id","subj":"941","obj":"Gene:3383"},{"id":"A942","pred":"tao:has_database_id","subj":"942","obj":"Gene:7412"},{"id":"A943","pred":"tao:has_database_id","subj":"943","obj":"Tax:10116"},{"id":"A944","pred":"tao:has_database_id","subj":"944","obj":"MESH:D006973"},{"id":"A945","pred":"tao:has_database_id","subj":"945","obj":"MESH:D006965"},{"id":"A946","pred":"tao:has_database_id","subj":"946","obj":"MESH:D007249"},{"id":"A947","pred":"tao:has_database_id","subj":"947","obj":"MESH:D007249"},{"id":"A953","pred":"tao:has_database_id","subj":"953","obj":"Tax:9091"},{"id":"A954","pred":"tao:has_database_id","subj":"954","obj":"MESH:D003300"},{"id":"A955","pred":"tao:has_database_id","subj":"955","obj":"MESH:D003300"},{"id":"A956","pred":"tao:has_database_id","subj":"956","obj":"MESH:D003300"},{"id":"A957","pred":"tao:has_database_id","subj":"957","obj":"MESH:D001102"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

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{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T27","span":{"begin":167,"end":172},"obj":"Body_part"},{"id":"T28","span":{"begin":405,"end":409},"obj":"Body_part"},{"id":"T29","span":{"begin":584,"end":597},"obj":"Body_part"},{"id":"T30","span":{"begin":670,"end":679},"obj":"Body_part"},{"id":"T31","span":{"begin":718,"end":726},"obj":"Body_part"},{"id":"T32","span":{"begin":761,"end":764},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0005079"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0005079"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0007379"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T193","span":{"begin":306,"end":317},"obj":"Disease"},{"id":"T194","span":{"begin":332,"end":344},"obj":"Disease"},{"id":"T195","span":{"begin":548,"end":560},"obj":"Disease"},{"id":"T196","span":{"begin":608,"end":624},"obj":"Disease"}],"attributes":[{"id":"A193","pred":"mondo_id","subj":"T193","obj":"http://purl.obolibrary.org/obo/MONDO_0005043"},{"id":"A194","pred":"mondo_id","subj":"T194","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A195","pred":"mondo_id","subj":"T195","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T295","span":{"begin":117,"end":124},"obj":"http://purl.obolibrary.org/obo/PR_000018263"},{"id":"T296","span":{"begin":145,"end":148},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T297","span":{"begin":167,"end":172},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T298","span":{"begin":167,"end":172},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T299","span":{"begin":246,"end":254},"obj":"http://purl.obolibrary.org/obo/PR_000001327"},{"id":"T300","span":{"begin":296,"end":304},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T301","span":{"begin":584,"end":597},"obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"T302","span":{"begin":626,"end":627},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T303","span":{"begin":748,"end":751},"obj":"http://purl.obolibrary.org/obo/CLO_0003417"},{"id":"T304","span":{"begin":788,"end":791},"obj":"http://purl.obolibrary.org/obo/CLO_0003417"},{"id":"T305","span":{"begin":833,"end":835},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T214","span":{"begin":32,"end":38},"obj":"Chemical"},{"id":"T216","span":{"begin":70,"end":81},"obj":"Chemical"},{"id":"T217","span":{"begin":117,"end":124},"obj":"Chemical"},{"id":"T218","span":{"begin":292,"end":295},"obj":"Chemical"},{"id":"T219","span":{"begin":454,"end":463},"obj":"Chemical"},{"id":"T220","span":{"begin":562,"end":568},"obj":"Chemical"},{"id":"T221","span":{"begin":644,"end":650},"obj":"Chemical"},{"id":"T223","span":{"begin":825,"end":831},"obj":"Chemical"}],"attributes":[{"id":"A214","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A215","pred":"chebi_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/CHEBI_30052"},{"id":"A216","pred":"chebi_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A217","pred":"chebi_id","subj":"T217","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A218","pred":"chebi_id","subj":"T218","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A219","pred":"chebi_id","subj":"T219","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A220","pred":"chebi_id","subj":"T220","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A221","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A222","pred":"chebi_id","subj":"T221","obj":"http://purl.obolibrary.org/obo/CHEBI_30052"},{"id":"A223","pred":"chebi_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A224","pred":"chebi_id","subj":"T223","obj":"http://purl.obolibrary.org/obo/CHEBI_30052"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T28","span":{"begin":70,"end":99},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T29","span":{"begin":101,"end":104},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A28","pred":"meddra_id","subj":"T28","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A29","pred":"meddra_id","subj":"T29","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T123","span":{"begin":167,"end":172},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T124","span":{"begin":380,"end":390},"obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"T125","span":{"begin":524,"end":534},"obj":"http://purl.obolibrary.org/obo/CL_0000738"},{"id":"T126","span":{"begin":614,"end":624},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T134","span":{"begin":32,"end":38},"obj":"Chemical"},{"id":"T136","span":{"begin":70,"end":81},"obj":"Chemical"},{"id":"T137","span":{"begin":117,"end":124},"obj":"Chemical"},{"id":"T138","span":{"begin":292,"end":295},"obj":"Chemical"},{"id":"T139","span":{"begin":562,"end":568},"obj":"Chemical"},{"id":"T140","span":{"begin":644,"end":650},"obj":"Chemical"},{"id":"T142","span":{"begin":825,"end":831},"obj":"Chemical"}],"attributes":[{"id":"A134","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A135","pred":"chebi_id","subj":"T134","obj":"http://purl.obolibrary.org/obo/CHEBI_30052"},{"id":"A136","pred":"chebi_id","subj":"T136","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"},{"id":"A137","pred":"chebi_id","subj":"T137","obj":"http://purl.obolibrary.org/obo/CHEBI_16670"},{"id":"A138","pred":"chebi_id","subj":"T138","obj":"http://purl.obolibrary.org/obo/CHEBI_63620"},{"id":"A139","pred":"chebi_id","subj":"T139","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A140","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A141","pred":"chebi_id","subj":"T140","obj":"http://purl.obolibrary.org/obo/CHEBI_30052"},{"id":"A142","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_28694"},{"id":"A143","pred":"chebi_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/CHEBI_30052"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T237","span":{"begin":198,"end":202},"obj":"Species"},{"id":"T240","span":{"begin":692,"end":697},"obj":"Species"}],"attributes":[{"id":"A237","pred":"ncbi_taxonomy_id","subj":"T237","obj":"NCBItxid:10118"},{"id":"A238","pred":"ncbi_taxonomy_id","subj":"T237","obj":"NCBItxid:10116"},{"id":"A239","pred":"ncbi_taxonomy_id","subj":"T237","obj":"NCBItxid:10114"},{"id":"A240","pred":"ncbi_taxonomy_id","subj":"T240","obj":"NCBItxid:8782"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T213","span":{"begin":0,"end":38},"obj":"Sentence"},{"id":"T214","span":{"begin":39,"end":208},"obj":"Sentence"},{"id":"T215","span":{"begin":209,"end":391},"obj":"Sentence"},{"id":"T216","span":{"begin":392,"end":561},"obj":"Sentence"},{"id":"T217","span":{"begin":562,"end":625},"obj":"Sentence"},{"id":"T218","span":{"begin":626,"end":698},"obj":"Sentence"},{"id":"T219","span":{"begin":699,"end":837},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T27","span":{"begin":167,"end":172},"obj":"Body_part"},{"id":"T28","span":{"begin":405,"end":409},"obj":"Body_part"},{"id":"T29","span":{"begin":584,"end":597},"obj":"Body_part"},{"id":"T30","span":{"begin":670,"end":679},"obj":"Body_part"},{"id":"T31","span":{"begin":718,"end":726},"obj":"Body_part"},{"id":"T32","span":{"begin":761,"end":764},"obj":"Body_part"}],"attributes":[{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A29","pred":"uberon_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/UBERON_0002405"},{"id":"A30","pred":"uberon_id","subj":"T30","obj":"http://purl.obolibrary.org/obo/UBERON_0005079"},{"id":"A31","pred":"uberon_id","subj":"T31","obj":"http://purl.obolibrary.org/obo/UBERON_0005079"},{"id":"A32","pred":"uberon_id","subj":"T32","obj":"http://purl.obolibrary.org/obo/UBERON_0007379"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

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"},{"id":"A2544","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/Q6NUP8"},{"id":"A2545","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/Q63669"},{"id":"A2546","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/Q5FVS3"},{"id":"A2547","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/Q28260"},{"id":"A2548","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/P29534"},{"id":"A2549","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/P29533"},{"id":"A2550","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/P19320"},{"id":"A2551","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/E9PDD1"},{"id":"A2552","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/B4DKS4"},{"id":"A2553","pred":"uniprot_id","subj":"T2544","obj":"https://www.uniprot.org/uniprot/A8K6R7"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

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Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T10","span":{"begin":39,"end":42},"obj":"http://purl.obolibrary.org/obo/MAT_0000213"},{"id":"T11","span":{"begin":167,"end":172},"obj":"http://purl.obolibrary.org/obo/MAT_0000083"},{"id":"T12","span":{"begin":167,"end":172},"obj":"http://purl.obolibrary.org/obo/MAT_0000315"},{"id":"T13","span":{"begin":405,"end":409},"obj":"http://purl.obolibrary.org/obo/MAT_0000091"},{"id":"T14","span":{"begin":661,"end":665},"obj":"http://purl.obolibrary.org/obo/MAT_0000213"},{"id":"T15","span":{"begin":761,"end":764},"obj":"http://purl.obolibrary.org/obo/MAT_0000213"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T49","span":{"begin":224,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T50","span":{"begin":332,"end":344},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T51","span":{"begin":366,"end":376},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T52","span":{"begin":423,"end":433},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T53","span":{"begin":548,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T54","span":{"begin":608,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T185","span":{"begin":167,"end":172},"obj":"Body_part"},{"id":"T186","span":{"begin":244,"end":254},"obj":"Body_part"},{"id":"T187","span":{"begin":380,"end":390},"obj":"Body_part"},{"id":"T188","span":{"begin":405,"end":409},"obj":"Body_part"},{"id":"T189","span":{"begin":471,"end":475},"obj":"Body_part"},{"id":"T190","span":{"begin":524,"end":534},"obj":"Body_part"},{"id":"T191","span":{"begin":584,"end":597},"obj":"Body_part"}],"attributes":[{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma61792"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A189","pred":"fma_id","subj":"T189","obj":"http://purl.org/sig/ont/fma/fma67857"},{"id":"A190","pred":"fma_id","subj":"T190","obj":"http://purl.org/sig/ont/fma/fma62852"},{"id":"A191","pred":"fma_id","subj":"T191","obj":"http://purl.org/sig/ont/fma/fma9825"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T183","span":{"begin":306,"end":317},"obj":"Disease"},{"id":"T184","span":{"begin":332,"end":344},"obj":"Disease"},{"id":"T185","span":{"begin":548,"end":560},"obj":"Disease"},{"id":"T186","span":{"begin":608,"end":624},"obj":"Disease"}],"attributes":[{"id":"A183","pred":"mondo_id","subj":"T183","obj":"http://purl.obolibrary.org/obo/MONDO_0005043"},{"id":"A184","pred":"mondo_id","subj":"T184","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A185","pred":"mondo_id","subj":"T185","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A186","pred":"mondo_id","subj":"T186","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T44","span":{"begin":224,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T45","span":{"begin":332,"end":344},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T46","span":{"begin":366,"end":376},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T47","span":{"begin":423,"end":433},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T48","span":{"begin":548,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T49","span":{"begin":608,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T44","span":{"begin":224,"end":234},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T45","span":{"begin":332,"end":344},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T46","span":{"begin":366,"end":376},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T47","span":{"begin":423,"end":433},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T48","span":{"begin":548,"end":560},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T49","span":{"begin":608,"end":624},"obj":"http://purl.obolibrary.org/obo/GO_0016032"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T213","span":{"begin":0,"end":38},"obj":"Sentence"},{"id":"T214","span":{"begin":39,"end":208},"obj":"Sentence"},{"id":"T215","span":{"begin":209,"end":391},"obj":"Sentence"},{"id":"T216","span":{"begin":392,"end":561},"obj":"Sentence"},{"id":"T217","span":{"begin":562,"end":625},"obj":"Sentence"},{"id":"T218","span":{"begin":626,"end":698},"obj":"Sentence"},{"id":"T219","span":{"begin":699,"end":837},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}

{"project":"2_test","denotations":[{"id":"32413736-26016560-48112979","span":{"begin":204,"end":206},"obj":"26016560"},{"id":"32413736-18936883-48112980","span":{"begin":833,"end":835},"obj":"18936883"},{"id":"T22851","span":{"begin":204,"end":206},"obj":"26016560"},{"id":"T59191","span":{"begin":833,"end":835},"obj":"18936883"}],"text":"8 Eggs for increasing ACE2 and copper\nEgg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation.\nCopper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34]."}