8 Eggs for increasing ACE2 and copper Egg ovotransferrin contains an angiotensin-converting enzyme (ACE) inhibitory peptide, known as IRW, that has shown to decrease blood pressure in hypertensive rats [33]. Through the up-regulation of ACE2, E-cadherin, ABCB-1, and IRF-8, IRW can decrease RAS activity, hyperplasia, and vascular inflammation and aid differential regulation of leukocytes. On the other hand, by the down-regulation of pro-inflammatory molecules, e.g., ICAM-1 and VCAM-1, IRW can reduce the recruitment of leukocytes and vascular inflammation. Copper might help the immune system to combat viral infections. A High-content of copper exists in eggs and eggshells of domestic birds. In particular, the eggshell of pigeon (4 ± 0.29 μg/g) and the egg of quail (4.67 ± 1.08 μg/g) contains high concentrations of copper [34].