PMC:7205724 / 19472-20478
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
665 | 321-330 | Species | denotes | SARS-CoV2 | Tax:2697049 |
679 | 473-477 | Gene | denotes | ACE2 | Gene:103231639 |
680 | 371-380 | Species | denotes | SARS-CoV2 | Tax:2697049 |
681 | 506-515 | Species | denotes | SARS-CoV2 | Tax:2697049 |
682 | 584-592 | Species | denotes | SARS-CoV | Tax:694009 |
683 | 666-675 | Species | denotes | SARS-CoV2 | Tax:2697049 |
684 | 734-742 | Species | denotes | SARS-CoV | Tax:694009 |
685 | 843-852 | Species | denotes | SARS-CoV2 | Tax:2697049 |
686 | 857-865 | Species | denotes | SARS-CoV | Tax:694009 |
687 | 360-369 | Disease | denotes | infection | MESH:D007239 |
688 | 516-525 | Disease | denotes | infection | MESH:D007239 |
689 | 714-723 | Disease | denotes | infection | MESH:D007239 |
690 | 804-813 | Disease | denotes | infection | MESH:D007239 |
691 | 449-451 | CellLine | denotes | E6 | CVCL:4582 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T147 | 452-457 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T148 | 942-950 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T139 | 321-325 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T140 | 360-369 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T141 | 371-375 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T142 | 506-510 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T143 | 516-525 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T144 | 584-592 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T145 | 666-670 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T146 | 714-723 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T147 | 734-742 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T148 | 804-813 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T149 | 843-847 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
T150 | 857-865 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T231 | 54-55 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T232 | 101-102 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T233 | 349-351 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
T234 | 444-457 | http://purl.obolibrary.org/obo/CLO_0051719 | denotes | Vero E6 cells |
T235 | 703-705 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
T236 | 793-795 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
T237 | 960-967 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T166 | 942-950 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sample-PD-IDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T82 | 143-154 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T83 | 194-210 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T84 | 331-342 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T85 | 360-369 | http://purl.obolibrary.org/obo/IDO_0000586 | denotes | infection |
T86 | 381-392 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T87 | 452-457 | http://purl.obolibrary.org/obo/CL_0000000 | denotes | cells |
T88 | 491-502 | http://purl.obolibrary.org/obo/IDO_0000467 | denotes | susceptible |
T89 | 516-525 | http://purl.obolibrary.org/obo/IDO_0000586 | denotes | infection |
T90 | 559-570 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T91 | 676-687 | http://purl.obolibrary.org/obo/IDO_0000608 | denotes | replication |
T92 | 714-723 | http://purl.obolibrary.org/obo/IDO_0000586 | denotes | infection |
T93 | 804-813 | http://purl.obolibrary.org/obo/IDO_0000586 | denotes | infection |
T94 | 960-967 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
LitCovid-sample-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T108 | 942-950 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
LitCovid-sample-PD-NCBITaxon
Id | Subject | Object | Predicate | Lexical cue | ncbi_taxonomy_id |
---|---|---|---|---|---|
T186 | 321-330 | Species | denotes | SARS-CoV2 | NCBItxid:2697049 |
T187 | 371-380 | Species | denotes | SARS-CoV2 | NCBItxid:2697049 |
T188 | 506-515 | Species | denotes | SARS-CoV2 | NCBItxid:2697049 |
T189 | 584-592 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T190 | 666-675 | Species | denotes | SARS-CoV2 | NCBItxid:2697049 |
T191 | 734-742 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T192 | 843-852 | Species | denotes | SARS-CoV2 | NCBItxid:2697049 |
T193 | 857-865 | Species | denotes | SARS-CoV | NCBItxid:694009 |
T194 | 960-967 | Species | denotes | viruses | NCBItxid:10239 |
LitCovid-sample-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T154 | 0-25 | Sentence | denotes | 5 Recombinant type I IFN |
T155 | 27-83 | Sentence | denotes | 5.1 Hypothesis: IFNs play a role in anti-viral immunity |
T156 | 84-257 | Sentence | denotes | Type I IFNs play a primary role in the inhibition of viral replication through the coordination of anti-viral immune responses and modulation of inflammatory responses [24]. |
T157 | 259-273 | Sentence | denotes | 5.2 Rational: |
T158 | 274-342 | Sentence | denotes | Recombinant type I IFN can effectively inhibit SARS-CoV2 replication |
T159 | 343-531 | Sentence | denotes | In 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. |
T160 | 532-598 | Sentence | denotes | It is similar to the viral replication kinetics for SARS-CoV [25]. |
T161 | 599-729 | Sentence | denotes | Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. |
T162 | 730-819 | Sentence | denotes | For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. |
T163 | 820-1006 | Sentence | denotes | The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]. |
LitCovid-sample-Pubtator
Id | Subject | Object | Predicate | Lexical cue | pubann:denotes |
---|---|---|---|---|---|
665 | 321-330 | Species | denotes | SARS-CoV2 | Tax:2697049 |
687 | 360-369 | Disease | denotes | infection | MESH:D007239 |
680 | 371-380 | Species | denotes | SARS-CoV2 | Tax:2697049 |
691 | 449-451 | CellLine | denotes | E6 | CVCL:4582 |
679 | 473-477 | Gene | denotes | ACE2 | Gene:103231639 |
681 | 506-515 | Species | denotes | SARS-CoV2 | Tax:2697049 |
688 | 516-525 | Disease | denotes | infection | MESH:D007239 |
682 | 584-592 | Species | denotes | SARS-CoV | Tax:694009 |
683 | 666-675 | Species | denotes | SARS-CoV2 | Tax:2697049 |
689 | 714-723 | Disease | denotes | infection | MESH:D007239 |
684 | 734-742 | Species | denotes | SARS-CoV | Tax:694009 |
690 | 804-813 | Disease | denotes | infection | MESH:D007239 |
685 | 843-852 | Species | denotes | SARS-CoV2 | Tax:2697049 |
686 | 857-865 | Species | denotes | SARS-CoV | Tax:694009 |
LitCovid-sample-UniProt
Id | Subject | Object | Predicate | Lexical cue | uniprot_id |
---|---|---|---|---|---|
T1989 | 931-950 | Protein | denotes | structural proteins | https://www.uniprot.org/uniprot/Q6LEG6|https://www.uniprot.org/uniprot/Q04766|https://www.uniprot.org/uniprot/Q04765 |
T1992 | 979-983 | Protein | denotes | NSP3 | https://www.uniprot.org/uniprot/Q9QNA7|https://www.uniprot.org/uniprot/Q9PY95|https://www.uniprot.org/uniprot/Q9ICB2|https://www.uniprot.org/uniprot/Q91ME7|https://www.uniprot.org/uniprot/Q8UZL8|https://www.uniprot.org/uniprot/Q8B6X8|https://www.uniprot.org/uniprot/Q8B6X7|https://www.uniprot.org/uniprot/Q86504|https://www.uniprot.org/uniprot/Q86196|https://www.uniprot.org/uniprot/Q85014|https://www.uniprot.org/uniprot/Q82054|https://www.uniprot.org/uniprot/Q82053|https://www.uniprot.org/uniprot/Q82052|https://www.uniprot.org/uniprot/Q82051|https://www.uniprot.org/uniprot/Q82050|https://www.uniprot.org/uniprot/Q82049|https://www.uniprot.org/uniprot/Q65701|https://www.uniprot.org/uniprot/Q5Y9A9|https://www.uniprot.org/uniprot/Q5K037|https://www.uniprot.org/uniprot/Q45UF3|https://www.uniprot.org/uniprot/Q3ZK63|https://www.uniprot.org/uniprot/Q27PP2|https://www.uniprot.org/uniprot/Q0H8C1|https://www.uniprot.org/uniprot/Q00721|https://www.uniprot.org/uniprot/P34717|https://www.uniprot.org/uniprot/P27586|https://www.uniprot.org/uniprot/P04514|https://www.uniprot.org/uniprot/P03536|https://www.uniprot.org/uniprot/B3SRX7|https://www.uniprot.org/uniprot/B3SRW9|https://www.uniprot.org/uniprot/B3SRV3|https://www.uniprot.org/uniprot/B3SRU5|https://www.uniprot.org/uniprot/B3SRS9|https://www.uniprot.org/uniprot/B3SRS1|https://www.uniprot.org/uniprot/B3SRR3|https://www.uniprot.org/uniprot/B3SRQ5|https://www.uniprot.org/uniprot/B2BRG4|https://www.uniprot.org/uniprot/A4ZCW4|https://www.uniprot.org/uniprot/A3DSK9|https://www.uniprot.org/uniprot/A2T3N5|https://www.uniprot.org/uniprot/A1YTU9 |
T2033 | 996-1000 | Protein | denotes | ORF6 | https://www.uniprot.org/uniprot/P51707|https://www.uniprot.org/uniprot/P42541|https://www.uniprot.org/uniprot/P0DTC6 |
LitCovid-sample-Enju
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T52733 | 0-1 | CD | denotes | 5 |
T83488 | 3-14 | JJ | denotes | Recombinant |
T93217 | 15-19 | NN | denotes | type |
T64716 | 20-21 | CD | denotes | I |
T68579 | 22-25 | NN | denotes | IFN |
T12001 | 27-30 | CD | denotes | 5.1 |
T9969 | 32-42 | NN | denotes | Hypothesis |
T15939 | 42-43 | -COLON- | denotes | : |
T64893 | 44-48 | NNS | denotes | IFNs |
T64532 | 49-53 | VBP | denotes | play |
T66496 | 54-55 | DT | denotes | a |
T99130 | 56-60 | NN | denotes | role |
T16405 | 61-63 | IN | denotes | in |
T11399 | 64-74 | JJ | denotes | anti-viral |
T89696 | 75-83 | NN | denotes | immunity |
T96681 | 84-88 | NN | denotes | Type |
T4789 | 89-90 | CD | denotes | I |
T85645 | 91-95 | NNS | denotes | IFNs |
T76626 | 96-100 | VBP | denotes | play |
T51847 | 101-102 | DT | denotes | a |
T51548 | 103-110 | JJ | denotes | primary |
T78533 | 111-115 | NN | denotes | role |
T65875 | 116-118 | IN | denotes | in |
T16934 | 119-122 | DT | denotes | the |
T59480 | 123-133 | NN | denotes | inhibition |
T64120 | 134-136 | IN | denotes | of |
T42209 | 137-142 | JJ | denotes | viral |
T92412 | 143-154 | NN | denotes | replication |
T19053 | 155-162 | IN | denotes | through |
T85138 | 163-166 | DT | denotes | the |
T89603 | 167-179 | NN | denotes | coordination |
T52542 | 180-182 | IN | denotes | of |
T13645 | 183-193 | JJ | denotes | anti-viral |
T39632 | 194-200 | JJ | denotes | immune |
T42144 | 201-210 | NNS | denotes | responses |
T54149 | 211-214 | CC | denotes | and |
T13001 | 215-225 | NN | denotes | modulation |
T2287 | 226-228 | IN | denotes | of |
T72730 | 229-241 | JJ | denotes | inflammatory |
T37912 | 242-251 | NNS | denotes | responses |
T64464 | 252-253 | -LRB- | denotes | [ |
T89396 | 253-255 | CD | denotes | 24 |
T17915 | 255-256 | -RRB- | denotes | ] |
T44068 | 259-262 | CD | denotes | 5.2 |
T95208 | 264-272 | NNP | denotes | Rational |
T91019 | 272-273 | -COLON- | denotes | : |
T95927 | 274-285 | JJ | denotes | Recombinant |
T3712 | 286-290 | NN | denotes | type |
T46872 | 291-292 | CD | denotes | I |
T95232 | 293-296 | NN | denotes | IFN |
T83801 | 297-300 | MD | denotes | can |
T31121 | 301-312 | RB | denotes | effectively |
T50200 | 313-320 | VB | denotes | inhibit |
T51383 | 321-330 | NN | denotes | SARS-CoV2 |
T97492 | 331-342 | NN | denotes | replication |
T96177 | 343-345 | IN | denotes | In |
T72452 | 346-353 | NN | denotes | 24–48 h |
T50493 | 354-359 | IN | denotes | after |
T17096 | 360-369 | NN | denotes | infection |
T97012 | 369-370 | -COMMA- | denotes | , |
T67170 | 371-380 | NN | denotes | SARS-CoV2 |
T9761 | 381-392 | NN | denotes | replication |
T69880 | 393-400 | VBZ | denotes | reaches |
T9709 | 401-406 | NN | denotes | titer |
T49785 | 407-411 | WDT | denotes | that |
T71708 | 412-418 | VBZ | denotes | causes |
T52777 | 419-422 | DT | denotes | the |
T56623 | 423-433 | JJ | denotes | cytopathic |
T87850 | 434-440 | NN | denotes | effect |
T47272 | 441-443 | IN | denotes | in |
T71726 | 444-448 | NN | denotes | Vero |
T42629 | 449-451 | NN | denotes | E6 |
T73531 | 452-457 | NNS | denotes | cells |
T60353 | 457-458 | -COMMA- | denotes | , |
T83400 | 459-464 | WDT | denotes | which |
T80948 | 465-472 | VBP | denotes | express |
T12338 | 473-477 | NN | denotes | ACE2 |
T60658 | 478-481 | CC | denotes | and |
T41368 | 482-486 | RB | denotes | thus |
T89464 | 487-490 | VBP | denotes | are |
T62340 | 491-502 | JJ | denotes | susceptible |
T6873 | 503-505 | TO | denotes | to |
T68175 | 506-515 | NN | denotes | SARS-CoV2 |
T16296 | 516-525 | NN | denotes | infection |
T12529 | 526-527 | -LRB- | denotes | [ |
T55131 | 527-529 | CD | denotes | 25 |
T28678 | 529-530 | -RRB- | denotes | ] |
T52876 | 532-534 | PRP | denotes | It |
T21084 | 535-537 | VBZ | denotes | is |
T70918 | 538-545 | JJ | denotes | similar |
T20327 | 546-548 | TO | denotes | to |
T13471 | 549-552 | DT | denotes | the |
T26039 | 553-558 | JJ | denotes | viral |
T64125 | 559-570 | NN | denotes | replication |
T62855 | 571-579 | NNS | denotes | kinetics |
T68614 | 580-583 | IN | denotes | for |
T64958 | 584-592 | NN | denotes | SARS-CoV |
T62199 | 593-594 | -LRB- | denotes | [ |
T27403 | 594-596 | CD | denotes | 25 |
T34963 | 596-597 | -RRB- | denotes | ] |
T49689 | 599-611 | NN | denotes | Pretreatment |
T74739 | 612-616 | IN | denotes | with |
T62356 | 617-628 | JJ | denotes | recombinant |
T67333 | 629-633 | NN | denotes | type |
T31833 | 634-635 | CD | denotes | I |
T78772 | 636-639 | NN | denotes | IFN |
T57406 | 640-645 | MD | denotes | could |
T5100 | 646-657 | RB | denotes | effectively |
T32529 | 658-665 | VB | denotes | inhibit |
T31501 | 666-675 | NN | denotes | SARS-CoV2 |
T43668 | 676-687 | NN | denotes | replication |
T86722 | 688-690 | IN | denotes | at |
T26971 | 691-695 | CC | denotes | both |
T35627 | 696-698 | CD | denotes | 24 |
T29701 | 699-702 | CC | denotes | and |
T48153 | 703-707 | NN | denotes | 48 h |
T93874 | 708-713 | IN | denotes | after |
T7550 | 714-723 | NN | denotes | infection |
T23827 | 724-725 | -LRB- | denotes | [ |
T6071 | 725-727 | CD | denotes | 25 |
T91011 | 727-728 | -RRB- | denotes | ] |
T51029 | 730-733 | IN | denotes | For |
T64526 | 734-742 | NN | denotes | SARS-CoV |
T41819 | 742-743 | -COMMA- | denotes | , |
T5764 | 744-748 | PDT | denotes | such |
T79954 | 749-751 | DT | denotes | an |
T48924 | 752-758 | NN | denotes | effect |
T40034 | 759-762 | VBD | denotes | was |
T1935 | 763-770 | JJ | denotes | present |
T31311 | 771-773 | IN | denotes | at |
T94385 | 774-778 | CD | denotes | 24 h |
T84543 | 779-782 | CC | denotes | but |
T64490 | 783-789 | JJ | denotes | absent |
T33679 | 790-792 | IN | denotes | at |
T68271 | 793-797 | NN | denotes | 48 h |
T69307 | 798-803 | IN | denotes | after |
T51672 | 804-813 | NN | denotes | infection |
T85433 | 814-815 | -LRB- | denotes | [ |
T72350 | 815-817 | CD | denotes | 25 |
T63406 | 817-818 | -RRB- | denotes | ] |
T46096 | 820-823 | DT | denotes | The |
T71403 | 824-834 | NN | denotes | difference |
T17651 | 835-842 | IN | denotes | between |
T77482 | 843-852 | NN | denotes | SARS-CoV2 |
T6733 | 853-856 | CC | denotes | and |
T6622 | 857-865 | NN | denotes | SARS-CoV |
T66580 | 866-868 | IN | denotes | in |
T74975 | 869-877 | NN | denotes | response |
T1853 | 878-880 | TO | denotes | to |
T87892 | 881-885 | NN | denotes | type |
T83308 | 886-887 | CD | denotes | I |
T81934 | 888-891 | NN | denotes | IFN |
T42652 | 892-901 | NN | denotes | treatment |
T91527 | 902-905 | MD | denotes | may |
T42839 | 906-908 | VB | denotes | be |
T98810 | 909-912 | JJ | denotes | due |
T31126 | 913-915 | TO | denotes | to |
T23141 | 916-927 | NNS | denotes | differences |
T45488 | 928-930 | IN | denotes | in |
T39296 | 931-941 | JJ | denotes | structural |
T12723 | 942-950 | NNS | denotes | proteins |
T40582 | 951-953 | IN | denotes | of |
T48639 | 954-959 | DT | denotes | these |
T20513 | 960-967 | NNS | denotes | viruses |
T37519 | 967-968 | -COMMA- | denotes | , |
T18237 | 969-978 | VBG | denotes | including |
T17094 | 979-983 | NN | denotes | NSP3 |
T86991 | 983-984 | -COMMA- | denotes | , |
T14810 | 985-990 | NN | denotes | ORF3b |
T9269 | 990-991 | -COMMA- | denotes | , |
T18064 | 992-995 | CC | denotes | and |
T40695 | 996-1000 | NN | denotes | ORF6 |
T59456 | 1001-1002 | -LRB- | denotes | [ |
T34145 | 1002-1004 | CD | denotes | 25 |
T98303 | 1004-1005 | -RRB- | denotes | ] |
R49535 | T99130 | T66496 | arg1Of | role,a |
R82137 | T64532 | T16405 | arg1Of | play,in |
R93910 | T89696 | T16405 | arg2Of | immunity,in |
R53989 | T89696 | T11399 | arg1Of | immunity,anti-viral |
R24484 | T85645 | T96681 | arg1Of | IFNs,Type |
R82882 | T85645 | T4789 | arg1Of | IFNs,I |
R80452 | T85645 | T76626 | arg1Of | IFNs,play |
R9839 | T78533 | T76626 | arg2Of | role,play |
R78526 | T78533 | T51847 | arg1Of | role,a |
R6704 | T78533 | T51548 | arg1Of | role,primary |
R74996 | T76626 | T65875 | arg1Of | play,in |
R31420 | T69880 | T96177 | arg1Of | reaches,In |
R8938 | T72452 | T96177 | arg2Of | 24–48 h,In |
R22070 | T72452 | T50493 | arg1Of | 24–48 h,after |
R29558 | T17096 | T50493 | arg2Of | infection,after |
R81743 | T69880 | T97012 | arg1Of | reaches,"," |
R54619 | T9761 | T67170 | arg1Of | replication,SARS-CoV2 |
R28733 | T9761 | T69880 | arg1Of | replication,reaches |
R54888 | T9709 | T69880 | arg2Of | titer,reaches |
R54019 | T9709 | T49785 | arg1Of | titer,that |
R2019 | T9709 | T71708 | arg1Of | titer,causes |
R69166 | T87850 | T71708 | arg2Of | effect,causes |
R70600 | T87850 | T52777 | arg1Of | effect,the |
R54949 | T87850 | T56623 | arg1Of | effect,cytopathic |
R44193 | T68579 | T52733 | arg1Of | IFN,5 |
R5826 | T68579 | T83488 | arg1Of | IFN,Recombinant |
R80234 | T68579 | T93217 | arg1Of | IFN,type |
R96417 | T68579 | T64716 | arg1Of | IFN,I |
R50529 | T9969 | T12001 | arg1Of | Hypothesis,5.1 |
R73746 | T9969 | T15939 | arg1Of | Hypothesis,: |
R48761 | T64532 | T15939 | arg2Of | play,: |
R11011 | T64893 | T64532 | arg1Of | IFNs,play |
R56923 | T99130 | T64532 | arg2Of | role,play |
R7798 | T59480 | T65875 | arg2Of | inhibition,in |
R26292 | T59480 | T16934 | arg1Of | inhibition,the |
R3018 | T59480 | T64120 | arg1Of | inhibition,of |
R88840 | T92412 | T64120 | arg2Of | replication,of |
R43315 | T92412 | T42209 | arg1Of | replication,viral |
R45666 | T76626 | T19053 | arg1Of | play,through |
R41012 | T54149 | T19053 | arg2Of | and,through |
R49957 | T54149 | T85138 | arg1Of | and,the |
R10665 | T89603 | T52542 | arg1Of | coordination,of |
R3748 | T42144 | T52542 | arg2Of | responses,of |
R96444 | T42144 | T13645 | arg1Of | responses,anti-viral |
R11270 | T42144 | T39632 | arg1Of | responses,immune |
R93882 | T89603 | T54149 | arg1Of | coordination,and |
R64051 | T13001 | T54149 | arg2Of | modulation,and |
R35227 | T13001 | T2287 | arg1Of | modulation,of |
R46504 | T37912 | T2287 | arg2Of | responses,of |
R49745 | T37912 | T72730 | arg1Of | responses,inflammatory |
R59902 | T76626 | T64464 | arg1Of | play,[ |
R73394 | T89396 | T64464 | arg2Of | 24,[ |
R27076 | T17915 | T64464 | arg3Of | ],[ |
R12484 | T95208 | T44068 | arg1Of | Rational,5.2 |
R35124 | T95208 | T91019 | arg1Of | Rational,: |
R50751 | T95232 | T95927 | arg1Of | IFN,Recombinant |
R74572 | T95232 | T3712 | arg1Of | IFN,type |
R58753 | T95232 | T46872 | arg1Of | IFN,I |
R16030 | T95232 | T83801 | arg1Of | IFN,can |
R78959 | T50200 | T83801 | arg2Of | inhibit,can |
R77408 | T50200 | T31121 | arg1Of | inhibit,effectively |
R98880 | T95232 | T50200 | arg1Of | IFN,inhibit |
R90780 | T97492 | T50200 | arg2Of | replication,inhibit |
R70416 | T97492 | T51383 | arg1Of | replication,SARS-CoV2 |
R67236 | T71708 | T47272 | arg1Of | causes,in |
R90604 | T73531 | T47272 | arg2Of | cells,in |
R51483 | T73531 | T71726 | arg1Of | cells,Vero |
R13941 | T73531 | T42629 | arg1Of | cells,E6 |
R47369 | T73531 | T60353 | arg1Of | cells,"," |
R77344 | T73531 | T83400 | arg1Of | cells,which |
R51996 | T73531 | T80948 | arg1Of | cells,express |
R29937 | T12338 | T80948 | arg2Of | ACE2,express |
R56727 | T80948 | T60658 | arg1Of | express,and |
R89880 | T89464 | T60658 | arg2Of | are,and |
R41139 | T89464 | T41368 | arg1Of | are,thus |
R40674 | T73531 | T89464 | arg1Of | cells,are |
R2313 | T62340 | T89464 | arg2Of | susceptible,are |
R71574 | T73531 | T62340 | arg1Of | cells,susceptible |
R18320 | T62340 | T6873 | arg1Of | susceptible,to |
R10483 | T16296 | T6873 | arg2Of | infection,to |
R64279 | T16296 | T68175 | arg1Of | infection,SARS-CoV2 |
R82228 | T89464 | T12529 | arg1Of | are,[ |
R14351 | T55131 | T12529 | arg2Of | 25,[ |
R89760 | T28678 | T12529 | arg3Of | ],[ |
R98431 | T52876 | T21084 | arg1Of | It,is |
R14327 | T70918 | T21084 | arg2Of | similar,is |
R4320 | T52876 | T70918 | arg1Of | It,similar |
R34375 | T70918 | T20327 | arg1Of | similar,to |
R71339 | T62855 | T20327 | arg2Of | kinetics,to |
R35190 | T62855 | T13471 | arg1Of | kinetics,the |
R34673 | T62855 | T26039 | arg1Of | kinetics,viral |
R67158 | T62855 | T64125 | arg1Of | kinetics,replication |
R90913 | T70918 | T68614 | arg1Of | similar,for |
R5275 | T64958 | T68614 | arg2Of | SARS-CoV,for |
R43068 | T64958 | T62199 | arg1Of | SARS-CoV,[ |
R10807 | T27403 | T62199 | arg2Of | 25,[ |
R91008 | T34963 | T62199 | arg3Of | ],[ |
R68776 | T49689 | T74739 | arg1Of | Pretreatment,with |
R59690 | T78772 | T74739 | arg2Of | IFN,with |
R64010 | T78772 | T62356 | arg1Of | IFN,recombinant |
R73596 | T78772 | T67333 | arg1Of | IFN,type |
R44930 | T78772 | T31833 | arg1Of | IFN,I |
R49184 | T49689 | T57406 | arg1Of | Pretreatment,could |
R80908 | T32529 | T57406 | arg2Of | inhibit,could |
R7756 | T32529 | T5100 | arg1Of | inhibit,effectively |
R41655 | T49689 | T32529 | arg1Of | Pretreatment,inhibit |
R47659 | T43668 | T32529 | arg2Of | replication,inhibit |
R36370 | T43668 | T31501 | arg1Of | replication,SARS-CoV2 |
R34213 | T32529 | T86722 | arg1Of | inhibit,at |
R26206 | T29701 | T86722 | arg2Of | and,at |
R82903 | T29701 | T26971 | arg1Of | and,both |
R75547 | T35627 | T29701 | arg1Of | 24,and |
R90827 | T48153 | T29701 | arg2Of | 48 h,and |
R69068 | T32529 | T93874 | arg1Of | inhibit,after |
R47977 | T7550 | T93874 | arg2Of | infection,after |
R38076 | T7550 | T23827 | arg1Of | infection,[ |
R72421 | T6071 | T23827 | arg2Of | 25,[ |
R2860 | T91011 | T23827 | arg3Of | ],[ |
R21012 | T40034 | T51029 | arg1Of | was,For |
R42425 | T64526 | T51029 | arg2Of | SARS-CoV,For |
R88091 | T40034 | T41819 | arg1Of | was,"," |
R54495 | T48924 | T5764 | arg1Of | effect,such |
R26625 | T48924 | T79954 | arg1Of | effect,an |
R41534 | T48924 | T40034 | arg1Of | effect,was |
R24883 | T84543 | T40034 | arg2Of | but,was |
R86398 | T48924 | T1935 | arg1Of | effect,present |
R81876 | T1935 | T31311 | arg1Of | present,at |
R72270 | T94385 | T31311 | arg2Of | 24 h,at |
R12851 | T1935 | T84543 | arg1Of | present,but |
R60363 | T64490 | T84543 | arg2Of | absent,but |
R81621 | T48924 | T64490 | arg1Of | effect,absent |
R79664 | T84543 | T33679 | arg1Of | but,at |
R9487 | T68271 | T33679 | arg2Of | 48 h,at |
R71731 | T68271 | T69307 | arg1Of | 48 h,after |
R56025 | T51672 | T69307 | arg2Of | infection,after |
R2152 | T51672 | T85433 | arg1Of | infection,[ |
R22284 | T72350 | T85433 | arg2Of | 25,[ |
R9566 | T63406 | T85433 | arg3Of | ],[ |
R51347 | T71403 | T46096 | arg1Of | difference,The |
R4839 | T71403 | T17651 | arg1Of | difference,between |
R32316 | T6733 | T17651 | arg2Of | and,between |
R84108 | T77482 | T6733 | arg1Of | SARS-CoV2,and |
R18562 | T6622 | T6733 | arg2Of | SARS-CoV,and |
R2587 | T6733 | T66580 | arg1Of | and,in |
R24267 | T74975 | T66580 | arg2Of | response,in |
R82007 | T74975 | T1853 | arg1Of | response,to |
R35751 | T42652 | T1853 | arg2Of | treatment,to |
R70872 | T42652 | T87892 | arg1Of | treatment,type |
R16675 | T42652 | T83308 | arg1Of | treatment,I |
R93961 | T42652 | T81934 | arg1Of | treatment,IFN |
R17630 | T71403 | T91527 | arg1Of | difference,may |
R18684 | T42839 | T91527 | arg2Of | be,may |
R22926 | T71403 | T42839 | arg1Of | difference,be |
R74216 | T31126 | T42839 | arg2Of | to,be |
R18552 | T31126 | T98810 | arg1Of | to,due |
R78491 | T71403 | T31126 | arg1Of | difference,to |
R99441 | T23141 | T31126 | arg2Of | differences,to |
R87106 | T23141 | T45488 | arg1Of | differences,in |
R95354 | T12723 | T45488 | arg2Of | proteins,in |
R28120 | T12723 | T39296 | arg1Of | proteins,structural |
R78454 | T12723 | T40582 | arg1Of | proteins,of |
R26738 | T20513 | T40582 | arg2Of | viruses,of |
R35077 | T20513 | T48639 | arg1Of | viruses,these |
R70559 | T12723 | T37519 | arg1Of | proteins,"," |
R50810 | T12723 | T18237 | arg1Of | proteins,including |
R8147 | T18064 | T18237 | arg2Of | and,including |
R72409 | T17094 | T86991 | arg1Of | NSP3,"," |
R12802 | T14810 | T86991 | arg2Of | ORF3b,"," |
R29123 | T18064 | T9269 | arg1Of | and,"," |
R68379 | T86991 | T18064 | arg1Of | ",",and |
R4978 | T40695 | T18064 | arg2Of | ORF6,and |
R22872 | T18064 | T59456 | arg1Of | and,[ |
R60583 | T34145 | T59456 | arg2Of | 25,[ |
R50503 | T98303 | T59456 | arg3Of | ],[ |
LitCovid-sample-PD-GO-BP-0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T22 | 123-154 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibition of viral replication |
T23 | 137-154 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T24 | 137-154 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T25 | 194-210 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T26 | 229-251 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
T27 | 553-570 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T28 | 553-570 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T29 | 869-891 | http://purl.obolibrary.org/obo/GO_0034340 | denotes | response to type I IFN |
LitCovid-sample-PD-FMA
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T147 | 452-457 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T148 | 942-950 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-sample-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T134 | 321-330 | Disease | denotes | SARS-CoV2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T135 | 360-369 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T136 | 371-380 | Disease | denotes | SARS-CoV2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T137 | 506-515 | Disease | denotes | SARS-CoV2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T138 | 516-525 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T139 | 584-592 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T140 | 666-675 | Disease | denotes | SARS-CoV2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T141 | 714-723 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T142 | 734-742 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T143 | 804-813 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T144 | 843-852 | Disease | denotes | SARS-CoV2 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T145 | 857-865 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-sample-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T18 | 123-154 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibition of viral replication |
T19 | 137-154 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T20 | 137-154 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T21 | 194-210 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T22 | 229-251 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
T23 | 553-570 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T24 | 553-570 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T25 | 869-891 | http://purl.obolibrary.org/obo/GO_0034340 | denotes | response to type I IFN |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T18 | 123-154 | http://purl.obolibrary.org/obo/GO_1903901 | denotes | inhibition of viral replication |
T19 | 137-154 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T20 | 137-154 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T21 | 194-210 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune responses |
T22 | 229-251 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
T23 | 553-570 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T24 | 553-570 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
T25 | 869-891 | http://purl.obolibrary.org/obo/GO_0034340 | denotes | response to type I IFN |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T154 | 0-25 | Sentence | denotes | 5 Recombinant type I IFN |
T155 | 27-83 | Sentence | denotes | 5.1 Hypothesis: IFNs play a role in anti-viral immunity |
T156 | 84-257 | Sentence | denotes | Type I IFNs play a primary role in the inhibition of viral replication through the coordination of anti-viral immune responses and modulation of inflammatory responses [24]. |
T157 | 259-273 | Sentence | denotes | 5.2 Rational: |
T158 | 274-342 | Sentence | denotes | Recombinant type I IFN can effectively inhibit SARS-CoV2 replication |
T159 | 343-531 | Sentence | denotes | In 24–48 h after infection, SARS-CoV2 replication reaches titer that causes the cytopathic effect in Vero E6 cells, which express ACE2 and thus are susceptible to SARS-CoV2 infection [25]. |
T160 | 532-598 | Sentence | denotes | It is similar to the viral replication kinetics for SARS-CoV [25]. |
T161 | 599-729 | Sentence | denotes | Pretreatment with recombinant type I IFN could effectively inhibit SARS-CoV2 replication at both 24 and 48 h after infection [25]. |
T162 | 730-819 | Sentence | denotes | For SARS-CoV, such an effect was present at 24 h but absent at 48 h after infection [25]. |
T163 | 820-1006 | Sentence | denotes | The difference between SARS-CoV2 and SARS-CoV in response to type I IFN treatment may be due to differences in structural proteins of these viruses, including NSP3, ORF3b, and ORF6 [25]. |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32413736-10754318-48112978 | 253-255 | 10754318 | denotes | 24 |
T95987 | 253-255 | 10754318 | denotes | 24 |