1 Introduction Several generations have been exposed to COVID-19 under different conditions of life at varying locations around the world. As long as the COVID-19 continues to spread, its power of genome modification would probably be increased. What concerns us more is that the 2019-nCoV, by the process of modification of genome structure, might become more and more fitted to humans to profoundly affect those who have already escaped – children and young people without a pre-existing condition. No one can tell how much time it takes to reach a new level of perfection, and that the development of vaccines for active immunization is a long process. Moreover, most of the best available anti-viral agents are not helpful in the treatment of COVID-19. A randomized controlled trial of 199 hospitalized adults with confirmed COVID-19 demonstrated no actual difference between patients who received lopinavir-ritonavir and patients who received standard care alone in clinical improvement, death rate, and positive virus test rate at day 28 [1]. Here we review intermediate indicators of the pathogenesis of COVID-19 that have the potential of being considered for the treatment of COVID-19.