PMC:7205724 / 11503-12516 JSONTXT

{"project":"LitCovid-PubTator","denotations":[{"id":"361","span":{"begin":103,"end":112},"obj":"Species"},{"id":"380","span":{"begin":211,"end":214},"obj":"Gene"},{"id":"381","span":{"begin":405,"end":408},"obj":"Gene"},{"id":"382","span":{"begin":417,"end":420},"obj":"Gene"},{"id":"383","span":{"begin":776,"end":777},"obj":"Gene"},{"id":"384","span":{"begin":701,"end":702},"obj":"Gene"},{"id":"385","span":{"begin":243,"end":256},"obj":"Species"},{"id":"386","span":{"begin":315,"end":323},"obj":"Species"},{"id":"387","span":{"begin":375,"end":396},"obj":"Species"},{"id":"388","span":{"begin":413,"end":416},"obj":"Species"},{"id":"389","span":{"begin":473,"end":480},"obj":"Species"},{"id":"390","span":{"begin":505,"end":514},"obj":"Species"},{"id":"391","span":{"begin":587,"end":604},"obj":"Species"},{"id":"392","span":{"begin":612,"end":633},"obj":"Species"},{"id":"393","span":{"begin":718,"end":727},"obj":"Species"},{"id":"394","span":{"begin":803,"end":807},"obj":"Species"},{"id":"395","span":{"begin":817,"end":826},"obj":"Species"},{"id":"396","span":{"begin":910,"end":919},"obj":"Species"},{"id":"397","span":{"begin":966,"end":974},"obj":"Species"}],"attributes":[{"id":"A361","pred":"tao:has_database_id","subj":"361","obj":"Tax:2697049"},{"id":"A380","pred":"tao:has_database_id","subj":"380","obj":"Gene:22924"},{"id":"A381","pred":"tao:has_database_id","subj":"381","obj":"Gene:22924"},{"id":"A382","pred":"tao:has_database_id","subj":"382","obj":"Gene:22924"},{"id":"A383","pred":"tao:has_database_id","subj":"383","obj":"Gene:43740568"},{"id":"A384","pred":"tao:has_database_id","subj":"384","obj":"Gene:43740568"},{"id":"A385","pred":"tao:has_database_id","subj":"385","obj":"Tax:11118"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"Tax:694009"},{"id":"A387","pred":"tao:has_database_id","subj":"387","obj":"Tax:694009"},{"id":"A388","pred":"tao:has_database_id","subj":"388","obj":"Tax:11118"},{"id":"A389","pred":"tao:has_database_id","subj":"389","obj":"Tax:9606"},{"id":"A390","pred":"tao:has_database_id","subj":"390","obj":"Tax:2697049"},{"id":"A391","pred":"tao:has_database_id","subj":"391","obj":"Tax:2697049"},{"id":"A392","pred":"tao:has_database_id","subj":"392","obj":"Tax:694009"},{"id":"A393","pred":"tao:has_database_id","subj":"393","obj":"Tax:2697049"},{"id":"A394","pred":"tao:has_database_id","subj":"394","obj":"Tax:11118"},{"id":"A395","pred":"tao:has_database_id","subj":"395","obj":"Tax:694009"},{"id":"A396","pred":"tao:has_database_id","subj":"396","obj":"Tax:2697049"},{"id":"A397","pred":"tao:has_database_id","subj":"397","obj":"Tax:694009"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T84","span":{"begin":27,"end":33},"obj":"Body_part"},{"id":"T85","span":{"begin":170,"end":176},"obj":"Body_part"},{"id":"T86","span":{"begin":516,"end":519},"obj":"Body_part"},{"id":"T87","span":{"begin":568,"end":579},"obj":"Body_part"},{"id":"T88","span":{"begin":703,"end":710},"obj":"Body_part"},{"id":"T89","span":{"begin":778,"end":785},"obj":"Body_part"}],"attributes":[{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T71","span":{"begin":315,"end":323},"obj":"Disease"},{"id":"T72","span":{"begin":375,"end":379},"obj":"Disease"},{"id":"T73","span":{"begin":486,"end":490},"obj":"Disease"},{"id":"T74","span":{"begin":612,"end":616},"obj":"Disease"},{"id":"T75","span":{"begin":793,"end":797},"obj":"Disease"},{"id":"T76","span":{"begin":966,"end":974},"obj":"Disease"}],"attributes":[{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A74","pred":"mondo_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A75","pred":"mondo_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A76","pred":"mondo_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

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{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T122","span":{"begin":410,"end":412},"obj":"Chemical"},{"id":"T123","span":{"begin":568,"end":579},"obj":"Chemical"},{"id":"T124","span":{"begin":703,"end":710},"obj":"Chemical"},{"id":"T125","span":{"begin":778,"end":785},"obj":"Chemical"}],"attributes":[{"id":"A122","pred":"chebi_id","subj":"T122","obj":"http://purl.obolibrary.org/obo/CHEBI_74815"},{"id":"A123","pred":"chebi_id","subj":"T123","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A124","pred":"chebi_id","subj":"T124","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A125","pred":"chebi_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T8","span":{"begin":432,"end":454},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A8","pred":"meddra_id","subj":"T8","obj":"http://purl.bioontology.org/ontology/MEDDRA/10049413"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T50","span":{"begin":113,"end":118},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T83","span":{"begin":516,"end":519},"obj":"Chemical"},{"id":"T84","span":{"begin":568,"end":579},"obj":"Chemical"},{"id":"T85","span":{"begin":703,"end":710},"obj":"Chemical"},{"id":"T86","span":{"begin":778,"end":785},"obj":"Chemical"}],"attributes":[{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A84","pred":"chebi_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_33697"},{"id":"A86","pred":"chebi_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T86","span":{"begin":103,"end":112},"obj":"Species"},{"id":"T87","span":{"begin":158,"end":162},"obj":"Species"},{"id":"T88","span":{"begin":199,"end":202},"obj":"Species"},{"id":"T89","span":{"begin":315,"end":323},"obj":"Species"},{"id":"T90","span":{"begin":375,"end":396},"obj":"Species"},{"id":"T91","span":{"begin":486,"end":490},"obj":"Species"},{"id":"T92","span":{"begin":505,"end":514},"obj":"Species"},{"id":"T93","span":{"begin":612,"end":633},"obj":"Species"},{"id":"T94","span":{"begin":665,"end":669},"obj":"Species"},{"id":"T95","span":{"begin":718,"end":727},"obj":"Species"},{"id":"T96","span":{"begin":789,"end":807},"obj":"Species"},{"id":"T97","span":{"begin":817,"end":826},"obj":"Species"},{"id":"T98","span":{"begin":910,"end":919},"obj":"Species"},{"id":"T99","span":{"begin":966,"end":974},"obj":"Species"},{"id":"T100","span":{"begin":1008,"end":1012},"obj":"Species"}],"attributes":[{"id":"A93","pred":"ncbi_taxonomy_id","subj":"T93","obj":"NCBItxid:694009"},{"id":"A88","pred":"ncbi_taxonomy_id","subj":"T88","obj":"NCBItxid:9397"},{"id":"A92","pred":"ncbi_taxonomy_id","subj":"T92","obj":"NCBItxid:2697049"},{"id":"A94","pred":"ncbi_taxonomy_id","subj":"T94","obj":"NCBItxid:9397"},{"id":"A86","pred":"ncbi_taxonomy_id","subj":"T86","obj":"NCBItxid:2697049"},{"id":"A95","pred":"ncbi_taxonomy_id","subj":"T95","obj":"NCBItxid:2697049"},{"id":"A98","pred":"ncbi_taxonomy_id","subj":"T98","obj":"NCBItxid:2697049"},{"id":"A87","pred":"ncbi_taxonomy_id","subj":"T87","obj":"NCBItxid:9397"},{"id":"A90","pred":"ncbi_taxonomy_id","subj":"T90","obj":"NCBItxid:694009"},{"id":"A91","pred":"ncbi_taxonomy_id","subj":"T91","obj":"NCBItxid:694009"},{"id":"A100","pred":"ncbi_taxonomy_id","subj":"T100","obj":"NCBItxid:9397"},{"id":"A97","pred":"ncbi_taxonomy_id","subj":"T97","obj":"NCBItxid:694009"},{"id":"A96","pred":"ncbi_taxonomy_id","subj":"T96","obj":"NCBItxid:1508227"},{"id":"A99","pred":"ncbi_taxonomy_id","subj":"T99","obj":"NCBItxid:694009"},{"id":"A89","pred":"ncbi_taxonomy_id","subj":"T89","obj":"NCBItxid:694009"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

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Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T84","span":{"begin":27,"end":33},"obj":"Body_part"},{"id":"T85","span":{"begin":170,"end":176},"obj":"Body_part"},{"id":"T86","span":{"begin":516,"end":519},"obj":"Body_part"},{"id":"T87","span":{"begin":568,"end":579},"obj":"Body_part"},{"id":"T88","span":{"begin":703,"end":710},"obj":"Body_part"},{"id":"T89","span":{"begin":778,"end":785},"obj":"Body_part"}],"attributes":[{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A84","pred":"fma_id","subj":"T84","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma84116"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma67095"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T68","span":{"begin":315,"end":323},"obj":"Disease"},{"id":"T69","span":{"begin":375,"end":379},"obj":"Disease"},{"id":"T70","span":{"begin":486,"end":490},"obj":"Disease"},{"id":"T71","span":{"begin":612,"end":616},"obj":"Disease"},{"id":"T72","span":{"begin":793,"end":797},"obj":"Disease"},{"id":"T73","span":{"begin":966,"end":974},"obj":"Disease"}],"attributes":[{"id":"A72","pred":"mondo_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A69","pred":"mondo_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A70","pred":"mondo_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A71","pred":"mondo_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A68","pred":"mondo_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A73","pred":"mondo_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"LitCovid-sentences","denotations":[{"id":"T97","span":{"begin":0,"end":169},"obj":"Sentence"},{"id":"T98","span":{"begin":170,"end":346},"obj":"Sentence"},{"id":"T99","span":{"begin":347,"end":427},"obj":"Sentence"},{"id":"T100","span":{"begin":428,"end":515},"obj":"Sentence"},{"id":"T101","span":{"begin":516,"end":681},"obj":"Sentence"},{"id":"T102","span":{"begin":682,"end":859},"obj":"Sentence"},{"id":"T103","span":{"begin":860,"end":1013},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}

{"project":"2_test","denotations":[{"id":"32413736-16195424-48112970","span":{"begin":423,"end":425},"obj":"16195424"},{"id":"T82223","span":{"begin":423,"end":425},"obj":"16195424"}],"text":"4.1.2.1 Hypothesis: whole-genome sequencing and phylogenetic analysis shed light on the origin of the 2019-nCoV virus – It has been probably introduced from bats to men\nGenome sequencing of a fecal bat sample, Rp3, could detect an isolate of coronaviruses, which was almost identical to the causative agent of the SARS-CoV outbreak of 2002–2003. Hence, it attained the name SARS-like coronavirus isolate Rp3 (SL-CoV Rp3) [12]. The bronchoalveolar lavage fluid (BALF) of a patient with SARS contained the 2019-nCoV. RNA sequencing could reveal about 90% similarity in nucleotides of the novel coronavirus and of SARS-like coronavirus that had previously related to bats [13], [14]. In particular, the S protein of the 2019-nCoV has a high sequence identity of 80–98% with the S protein of bat SARS-like CoVs, such as SARSr-CoV ZXC21 S, ZC45 S, and RaTG13 [3]. Moreover, in phylogenomic trees, branches for the 2019-nCoV are of greater length than those for the 2003 SARS-CoV, and therefore more favorable to bats."}