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PMC:7200337 / 94716-96183 JSONTXT

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2_test

Id Subject Object Predicate Lexical cue
32505227-32155444-46575426 139-143 32155444 denotes 2020
T4350 139-143 32155444 denotes 2020

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T736 261-266 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T737 590-598 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T738 767-772 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T739 937-945 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T740 994-1002 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T98 767-772 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T542 33-41 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T543 44-53 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T544 626-634 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T545 905-913 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T546 1011-1019 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T547 1084-1092 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T548 1207-1215 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T549 1288-1296 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T550 1406-1415 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T974 259-266 http://purl.obolibrary.org/obo/CL_0000236 denotes B cells
T975 807-809 http://purl.obolibrary.org/obo/CLO_0050050 denotes S1
T976 903-904 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T977 979-980 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T978 1175-1176 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T979 1241-1242 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T980 1243-1252 http://purl.obolibrary.org/obo/CLO_0036932 denotes hybridoma
T981 1263-1264 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T982 1326-1327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T983 1440-1441 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T210 252-258 http://purl.obolibrary.org/obo/GO_0007613 denotes memory
T211 590-622 http://purl.obolibrary.org/obo/GO_0097282 denotes antibody-mediated neutralization

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
3134 561-565 Gene denotes ACE2 Gene:59272
3135 681-685 Gene denotes ACE2 Gene:59272
3136 855-859 Gene denotes ACE2 Gene:59272
3137 1114-1118 Gene denotes ACE2 Gene:59272
3138 1389-1391 Gene denotes to Gene:6999
3139 1377-1379 Gene denotes to Gene:6999
3140 1070-1072 Gene denotes to Gene:6999
3141 804-806 Gene denotes to Gene:6999
3142 644-646 Gene denotes to Gene:6999
3143 317-319 Gene denotes to Gene:6999
3144 199-201 Gene denotes to Gene:6999
3145 0-8 Species denotes Patients Tax:9606
3146 626-636 Species denotes SARS-CoV-2 Tax:2697049
3147 789-797 Species denotes patients Tax:9606
3148 905-913 Species denotes SARS-CoV Tax:694009
3149 1011-1021 Species denotes SARS-CoV-2 Tax:2697049
3150 1084-1094 Species denotes SARS-CoV-2 Tax:2697049
3151 1207-1217 Species denotes SARS-CoV-2 Tax:2697049
3152 1288-1298 Species denotes SARS-CoV-2 Tax:2697049
3153 1380-1388 Species denotes patients Tax:9606
3154 328-339 Species denotes recombinant Tax:575864
3155 82-86 Chemical denotes nAbs
3156 215-219 Chemical denotes nAbs
3157 1276-1279 Chemical denotes nAb
3158 33-53 Disease denotes SARS-CoV-2 infection MESH:C000657245
3159 1406-1415 Disease denotes infection MESH:D007239

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T545 0-185 Sentence denotes Patients who have recovered from SARS-CoV-2 infection are one potential source of nAbs (Chen et al., 2020a, Ju et al., 2020, Walls et al., 2020, Wölfel et al., 2020, Yuan et al., 2020).
T546 186-416 Sentence denotes In an effort to obtain these nAbs, scientists sorted RBD-specific memory B cells and cloned their heavy and light variable regions to express recombinant forms of the corresponding antibodies (Chen et al., 2020a, Ju et al., 2020).
T547 417-578 Sentence denotes Four of the antibodies produced in these studies (31B5, 32D4, P2C-2F6, P2C-1F11) showed high neutralizing potential in vitro, and all inhibited ACE2-RBD binding.
T548 579-698 Sentence denotes Successful antibody-mediated neutralization of SARS-CoV-2 seemed to be dependent on the inhibition of ACE2/RBD binding.
T549 699-893 Sentence denotes However, Chen et al. showed that nearly all antibodies derived from serum of 26 recovered patients bound to S1 and RBD, with only three actually inhibiting ACE2/RBD binding (Chen et al., 2020a).
T550 894-1131 Sentence denotes Of note, a SARS-CoV-1-derived neutralizing antibody (47D11) (Wang et al., 2020a) and a single-chain antibody against SARS-CoV-2 (n3130) (Wu et al., 2020c) have also been shown to neutralize SARS-CoV-2 without inhibiting ACE2/RBD binding.
T551 1132-1222 Sentence denotes Thus, blocking this interaction may not be a prerequisite for an effective SARS-CoV-2 nAb.
T552 1223-1467 Sentence denotes The generation of a hybridoma producing a monoclonal nAb against SARS-CoV-2 provides the potential for a therapeutic Ab that can be directly administered to patients to block ongoing infection and potentially even as a prophylactic (Figure 6D).