kugamage et al., 2020, Mantlo et al., 2020, Stanifer et al., 2020). However, the specific IFN-stimulated genes (ISGs) that mediate these protective effects are still being elucidated. Lymphocyte antigen 6 complex locus E (LY6E) has been shown to interfere with SARS-CoV-2 spike (S)