L-8 production, potentially by inhibition of NKRF, an endogenous NF-kB repressor (Li et al., 2020a). Collectively, these proinflammatory processes likely contribute to the “cytokine storm” observed in COVID-19 patients and substantiate a role for targeted immunosuppressive treatment regimens. Moving forward, a clear understanding of the delicate balance between antiviral and inflammatory innate immune programs will be essential to developin