In our investigatory study, out of five, two proteins namely ORF-3a and ORF-7a specific to SARS-COV-2 were found to be putative T-cell epitope determinants that create useful information to distinguish, and these proteins are also important for viral replication and growth [41]. Both of these proteins may influence in viral pathogenesis and disease spread, although the literature lacks unanimity [43]. B-cell epitopes prediction is still considered to be untrustworthy for both linear and conformational epitopes as compared to T-cell epitopes. Furthermore, the B-cell epitopes do not elicit a strong antibody response. For this reason, only T-cell epitopes are considered in the present study. It is capable to produce CD4+ and CD8+ T-cells with long-lasting response [45]. . In one of the recent studies, epitopes were designed, but they have focused on the single protein (i.e. SPIKE protein) to generate multiple epitopes like 13 for MHC I and 3 for MHC II [46]. We have analyzed multiple proteins to screen only effective epitopes based on various in-silico filters, to provide the most appropriate and authentic epitopes, which can be further tested in a wet lab.