ITLCFTLKR epitope was selected for crafting and designing a vaccine against SARS-COV-2. This particular epitope has good antigenicity, exhibits active binding with MHC HLA-Alleles, and has maximum population coverage for different geographical regions. Therefore, this peptide can be further used in vaccine design against SARS-COV-2 after wet lab verification. This novel approach can also assist life science research groups to reduce time, monetary expenditures, as well as physical hit-trial efforts.