Satisfactory population coverage was observed for targeted epitopes - HLA allelic complexes at the worldwide, South Asia, and India level. The biochemical integrity in epitope structure was further evident by deploying Ramachandran plot analysis. Both epitopes were non-toxic, non-allergenic, and possess good antigenicity. In a similar study of the preliminary analysis of COVID-19 vaccine targets [1] the investigators tried to use the spike protein and nucleo-capsid protein sequences of SARS-COV that are homologous to some extant with SARS-COV-2 proteins to determine multiple different epitopes for Vaccine prediction, but in our study out of five two proteins namely ORF-3a and ORF-7a specific to SARS-COV-2 were found to be putative T-cell epitope determinants that create useful information; these proteins are also important for viral replication [41]. Both biochemical parameters, as well as an advanced HMM and ANN based algorithm in selected Immuno-informatics tools, were very useful to present a clear picture of predicted epitopes for crafting vaccine against SARS-COV-2. The only limitation that can be considered as future scope is that these easily synthesized peptides should be tested with In-vitro study for more practical validation.