We performed a single-center, observational cohort study. Because of the clinical emergency setting caused by the current pandemic, the local institutional review board approved the present prospective study (protocol no. PO-CVA-08), and all included patients had provided written informed consent. The data from all patients who had tested positive for COVID-19 and had presented with ALI requiring urgent operative intervention were collected in a prospectively maintained database. Data entry was managed by the physicians involved in direct patient care. For our study, the data from all the patients who had presented with and been treated for ALI were identified and analyzed. From an epidemiological viewpoint, we also compared the data with data from the same period in 2019. The recorded variables included demographic data, comorbidities, laboratory blood test results, including coagulation panels, medical and surgical history, operative details, and postoperative events during hospitalization and the immediate postoperative period.