The novel coronavirus pneumonia (COVID-19) pandemic has affected the globe, with Italy leading many reports of the incidence and mortalities. Within a few weeks in March 2020, the number of patients with the COVID-19 skyrocketed in northern Italy, especially in the Lombardy region, which has been speculated to have resulted from the older population in that region. Recently reported studies have described the clinical characteristics and overall outcomes of patients with COVID-19 and the effects of treating these patient on the healthcare system.4 Two studies have reported associated coagulopathy disorders. These reports have highlighted the presence of a coexisting hypercoagulable state in patients with COVID-19, which might be associated with higher mortality.5 , 6 A sudden and significant increase of COVID-19–infected patients who were presenting with ALI has been noted at our institutions with the viral spread. The aim of the present study was to determine the incidence, characteristics, and clinical outcomes of patients presenting with and treated for ALI during the COVID-19 pandemic at an Italian tertiary care hospital.