Article Highlights • Type of Research: Single-center, observational cohort study • Key Findings: The novel coronavirus (COVID-19) might increase the incidence of acute limb ischemia (ALI) in patients who test positive for the virus. Surgical revascularization was associated with a high technical failure rate in our cohort, which might have resulted from an inherent virus-related underlying hypercoagulability state. No significant demographic differences between those with and without successful revascularization were present in our cohort; however, age was significantly older for the patients who died. • Take Home Message: COVID-19 infection might increase the incidence of ALI and be associated with poorer surgical results owing to the associated acquired hypercoagulability. Prolonged systemic heparin might be warranted for both limb salvage and improved survival.