PMC:7187150 / 983-1461 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T18","span":{"begin":68,"end":75},"obj":"Body_part"},{"id":"T19","span":{"begin":100,"end":105},"obj":"Body_part"},{"id":"T20","span":{"begin":170,"end":179},"obj":"Body_part"},{"id":"T21","span":{"begin":203,"end":225},"obj":"Body_part"},{"id":"T22","span":{"begin":220,"end":225},"obj":"Body_part"},{"id":"T23","span":{"begin":231,"end":237},"obj":"Body_part"},{"id":"T24","span":{"begin":259,"end":279},"obj":"Body_part"},{"id":"T25","span":{"begin":274,"end":279},"obj":"Body_part"},{"id":"T26","span":{"begin":302,"end":306},"obj":"Body_part"},{"id":"T27","span":{"begin":307,"end":310},"obj":"Body_part"},{"id":"T28","span":{"begin":329,"end":335},"obj":"Body_part"},{"id":"T29","span":{"begin":389,"end":393},"obj":"Body_part"},{"id":"T30","span":{"begin":430,"end":435},"obj":"Body_part"},{"id":"T31","span":{"begin":454,"end":459},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"fma_id","subj":"T18","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A19","pred":"fma_id","subj":"T19","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A20","pred":"fma_id","subj":"T20","obj":"http://purl.org/sig/ont/fma/fma63194"},{"id":"A21","pred":"fma_id","subj":"T21","obj":"http://purl.org/sig/ont/fma/fma70570"},{"id":"A22","pred":"fma_id","subj":"T22","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A23","pred":"fma_id","subj":"T23","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A24","pred":"fma_id","subj":"T24","obj":"http://purl.org/sig/ont/fma/fma82841"},{"id":"A25","pred":"fma_id","subj":"T25","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A28","pred":"fma_id","subj":"T28","obj":"http://purl.org/sig/ont/fma/fma7203"},{"id":"A29","pred":"fma_id","subj":"T29","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A30","pred":"fma_id","subj":"T30","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A31","pred":"fma_id","subj":"T31","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T12","span":{"begin":100,"end":105},"obj":"Body_part"},{"id":"T13","span":{"begin":170,"end":179},"obj":"Body_part"},{"id":"T14","span":{"begin":231,"end":237},"obj":"Body_part"},{"id":"T15","span":{"begin":329,"end":335},"obj":"Body_part"}],"attributes":[{"id":"A12","pred":"uberon_id","subj":"T12","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/UBERON_0001982"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"A15","pred":"uberon_id","subj":"T15","obj":"http://purl.obolibrary.org/obo/UBERON_0002113"}],"text":"Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T13","span":{"begin":128,"end":136},"obj":"Disease"}],"attributes":[{"id":"A13","pred":"mondo_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T32","span":{"begin":100,"end":105},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T33","span":{"begin":164,"end":169},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T34","span":{"begin":215,"end":225},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T35","span":{"begin":231,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T36","span":{"begin":231,"end":237},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T37","span":{"begin":231,"end":237},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T38","span":{"begin":253,"end":258},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_9606"},{"id":"T39","span":{"begin":269,"end":279},"obj":"http://purl.obolibrary.org/obo/CL_0000034"},{"id":"T40","span":{"begin":302,"end":306},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T41","span":{"begin":329,"end":335},"obj":"http://purl.obolibrary.org/obo/UBERON_0002113"},{"id":"T42","span":{"begin":329,"end":335},"obj":"http://www.ebi.ac.uk/efo/EFO_0000927"},{"id":"T43","span":{"begin":329,"end":335},"obj":"http://www.ebi.ac.uk/efo/EFO_0000929"},{"id":"T44","span":{"begin":389,"end":393},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T45","span":{"begin":430,"end":435},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T46","span":{"begin":454,"end":459},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat."}

{"project":"LitCovid-sentences","denotations":[{"id":"T7","span":{"begin":0,"end":478},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat."}

{"project":"LitCovid-PubTator","denotations":[{"id":"44","span":{"begin":45,"end":49},"obj":"Gene"},{"id":"45","span":{"begin":358,"end":362},"obj":"Gene"},{"id":"46","span":{"begin":164,"end":169},"obj":"Species"},{"id":"47","span":{"begin":253,"end":258},"obj":"Species"},{"id":"52","span":{"begin":94,"end":117},"obj":"Disease"},{"id":"53","span":{"begin":128,"end":136},"obj":"Disease"}],"attributes":[{"id":"A44","pred":"tao:has_database_id","subj":"44","obj":"Gene:59272"},{"id":"A45","pred":"tao:has_database_id","subj":"45","obj":"Gene:59272"},{"id":"A46","pred":"tao:has_database_id","subj":"46","obj":"Tax:9606"},{"id":"A47","pred":"tao:has_database_id","subj":"47","obj":"Tax:9606"},{"id":"A52","pred":"tao:has_database_id","subj":"52","obj":"MESH:D009102"},{"id":"A53","pred":"tao:has_database_id","subj":"53","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Based on the hypothesis that the presence of ACE2 in extrapulmonary tissues might explain the multi-organ dysfunction caused by COVID-19, the researchers developed human capillary organoids from induced pluripotent stem cells, and kidney organoids from human embryonic stem cells. “Importantly, single-cell RNA sequencing of the kidney organoids showed that ACE2 is expressed in different cell populations, including tubular-like cells and podocyte-like cells,” says Montserrat."}