Regions under secondary threat The regions and areas other than the originating region of COVID-19 infection will be considered as the regions under secondary threat. In these regions, the stress and fear of infection along with other above-mentioned factors will likely generate moderate to major behavioral and psychological abnormalities (S10-S12). The overall impact of infection on mental health will be associated with the rate of infectiousness and mortality. The most common impacts of such an outbreak or epidemic could be anxiety, panic behavior, sleep disturbances, disrupted daily biological rhythms, anger, and disappointment (S10,S13-S15). In most cases, infected people make their utmost effort to avoid the spread of the virus in community however, some people don’t cooperate. It has been generally observed in several cities of China that foreigners (mostly students) find ways to flee. It may be due to the higher stress or fear; however, such actions may cause the viral spread in countries with no facilities for combating coronavirus. It will ultimately increase the burden of mental abnormalities in the respective population. To avoid the negative outcomes of such practices, the relevant forces should communicate people who can help them identify such individuals. It may be possible through facilitating the community by electronic and social media. Individuals who have moderate psychological disturbances can be handled by mental health professionals through relaxation and cognitive behavioral techniques, and/or medication if needed (S11,S16). Furthermore, people must be educated or made aware of the development of clinical depression, and suicidality related symptoms followed by the outbreak. Professional clinical psychologists or psychiatrists should come forward and communicate through media to encourage individuals for life and healthy activities. In addition, communities with certain beliefs should be benefited from spiritual education. Nevertheless, media can play a critical role by broadcasting instruction regarding relaxation, meditation, and advice to not focus on rumors and forged news from unauthentic sources.