Funding: The authors acknowledge the Postdoctoral research grant from The Second Affiliated Hospital of Zhengzhou University (for S.K) and the operating grant support from the National Natural Science Foundation of China (grants no: 81870942, 81471174 and 81520108011), National Key Research and Development Program of China (grant no: 2018YFC1312200), and Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China (for MX).