Funding This study was supported by the Science-Technology Foundation for Young Scientist of Gansu Province of China (Grant no.18JR3RA059) and the Young Scientists Fund of Gansu Provincial Hospital of China (Grant no.17GSS7–1). J Gao was supported by the Sigrid Jusélius Foundation, the Finnish Anti-Tuberculosis Association Foundation, the Jalmari and Rauha Ahokas Foundationm, and the Swedish Asthma and Allergy Foundation. CX Li was supported by the Mats Klebergs Stiftelse and the Swedish Heart-lung foundation.