Based the above analysis, we have the major conclusions as follows.(1) The COVID-19 disease variations can be simulated by our models with very high accuracy, including the cumulative confirmed cases and confirmed cases. (2) Under the present daily input population and quarantine strategy, the COVID-19 disease will become extinction in May 11, 2020, with the cumulative confirmed cases number of 1397. (3) In Guangdong province, the adjustment of the emergency response level of epidemic prevention and control from the first level response to the second level at Feb 24, 2020 is reasonable which is also predicted by our model. (4) The disease will have a second outbreak risk when the input population is remarkably increased and the present quarantine strategy rapidly decreases to the values around zero.