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PMC:7161517 / 8768-9732 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T51 24-28 Body_part denotes Axis http://purl.org/sig/ont/fma/fma12520
T52 396-411 Body_part denotes adrenal medulla http://purl.org/sig/ont/fma/fma15633
T53 416-436 Body_part denotes antidiuretic hormone http://purl.org/sig/ont/fma/fma74646
T54 446-465 Body_part denotes posterior pituitary http://purl.org/sig/ont/fma/fma74636

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T31 0-3 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T32 396-411 Body_part denotes adrenal medulla http://purl.obolibrary.org/obo/UBERON_0001236
T33 933-936 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229
T34 939-963 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T47 249-261 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T48 342-345 Disease denotes AT1 http://purl.obolibrary.org/obo/MONDO_0008840
T49 456-465 Disease denotes pituitary http://purl.obolibrary.org/obo/MONDO_0021156

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T102 446-455 http://purl.obolibrary.org/obo/UBERON_0001353 denotes posterior
T103 489-497 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T104 580-586 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T105 894-904 http://purl.obolibrary.org/obo/PR_000001898 denotes neprilysin

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T89 0-3 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T90 40-55 Chemical denotes Angiotensinogen http://purl.obolibrary.org/obo/CHEBI_2720
T91 72-83 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T92 131-133 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T93 138-149 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T94 197-207 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T95 226-237 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T96 299-301 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T97 322-324 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T98 365-376 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T100 429-436 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T101 467-478 Chemical denotes Aldosterone http://purl.obolibrary.org/obo/CHEBI_27584
T102 515-527 Chemical denotes Endothelin-1 http://purl.obolibrary.org/obo/CHEBI_80240
T103 537-548 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T104 630-632 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T105 872-876 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T107 905-911 Chemical denotes prolyl http://purl.obolibrary.org/obo/CHEBI_26274|http://purl.obolibrary.org/obo/CHEBI_32874
T109 927-930 Chemical denotes PEP http://purl.obolibrary.org/obo/CHEBI_18021|http://purl.obolibrary.org/obo/CHEBI_44897
T111 933-936 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620
T112 945-956 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T30 29-39 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T31 249-261 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T32 365-386 http://purl.obolibrary.org/obo/GO_0035932 denotes aldosterone secretion
T33 377-386 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T34 604-610 http://purl.obolibrary.org/obo/GO_0004707 denotes (ERK)1
T35 611-615 http://purl.obolibrary.org/obo/GO_0004707 denotes ERK2

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T59 40-104 Sentence denotes Angiotensinogen is converted to angiotensin I (Ang I) via renin.
T60 105-262 Sentence denotes Ang I is converted to Ang II via angiotensin-converting enzyme (ACE), which also hydrolyzes bradykinin into its inactive metabolites, promoting inflammation.
T61 263-466 Sentence denotes The pro-inflammatory effects of Ang II are mediated by Ang II type I receptor (AT1), which stimulates aldosterone secretion from the adrenal medulla and antidiuretic hormone from the posterior pituitary.
T62 467-514 Sentence denotes Aldosterone decreases membrane ACE2 expression.
T63 515-625 Sentence denotes Endothelin-1 inhibits angiotensin 1-7 (Ang1-7) via extracellular signal-regulated kinase (ERK)1/ERK2 pathways.
T64 626-779 Sentence denotes Ang II, under favorable conditions (dashed line), can be converted to Ang1-7 via ACE2, whose counter regulatory effects are mediated by the Mas receptor.
T65 780-932 Sentence denotes Ang1-7 can also be formed via conversion of Ang I to an intermediate Ang1-9 or directly via zinc metallopeptidase neprilysin/prolyl endopeptidase (PEP).
T66 933-964 Sentence denotes RAS = renin-angiotensin system.

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T273 8-12 G_3;PG_10;PR:000003622 denotes ACE2
T274 13-17 PR:000036013 denotes Ang1
T275 20-23 PR:000001563 denotes Mas
T276 29-55 GO:0065007 denotes Regulation Angiotensinogen
T277 72-85 PR:000036008 denotes angiotensin I
T278 87-92 PR:000036008 denotes Ang I
T279 98-103 PR:000013883 denotes renin
T280 105-110 PR:000036008 denotes Ang I
T281 127-133 PR:000036009 denotes Ang II
T282 186-196 MOP:0000619 denotes hydrolyzes
T283 197-207 CHEBI:3165;CHEBI:3165 denotes bradykinin
T284 226-237 CHEBI:25212;CHEBI:25212 denotes metabolites
T285 295-301 PR:000036009 denotes Ang II
T286 318-324 PR:000036009 denotes Ang II
T287 365-376 CHEBI:27584;CHEBI:27584 denotes aldosterone
T288 396-411 UBERON:0001236 denotes adrenal medulla
T289 456-465 UBERON:0002198 denotes pituitary
T290 467-478 CHEBI:27584;CHEBI:27584 denotes Aldosterone
T291 489-497 GO:0016020 denotes membrane
T292 498-502 G_3;PG_10;PR:000003622 denotes ACE2
T293 503-513 GO:0010467 denotes expression
T294 515-525 UBERON:0001986;PR:000006897 denotes Endothelin
T295 525-527 PR:000006897 denotes -1
T296 537-550 PR:000036013 denotes angiotensin 1
T297 554-558 PR:000036013 denotes Ang1
T298 566-579 GO:0005576 denotes extracellular
T299 587-596 GO:0065007 denotes regulated
T300 611-615 PR:000000103 denotes ERK2
T301 626-632 PR:000036009 denotes Ang II
T302 696-700 PR:000036013 denotes Ang1
T303 707-711 PR:000003622;G_3;PG_10 denotes ACE2
T304 780-785 PR:000036013 denotes Ang1-
T305 824-829 PR:000036008 denotes Ang I
T306 849-855 PR:000036012 denotes Ang1-9
T307 894-904 PR:000001898 denotes neprilysin
T308 939-944 PR:000013883 denotes renin
T49835 31-37 PR:000036009 denotes gulati
T23691 52-57 PR:000036013 denotes gen i
T96566 61-65 G_3;PG_10;PR:000003622 denotes nver
T43762 124-136 SP_10 denotes to Ang II vi
T84544 137-147 SP_10;UBERON:0001004 denotes angiotens
T62103 148-168 SP_10 denotes n-converting enzyme
T45099 170-178 SP_10 denotes CE), whi
T96697 186-194 SP_10 denotes hydrolyz
T67126 196-200 G_3;PG_10;PR:000003622 denotes bra
T70630 210-219 PG_1 denotes to its in
T4074 245-250 NCBITaxon:10239;GO:0035376 denotes ing i
T7619 251-256 GO:0035376 denotes flamm
T1702 266-278 GO:0044164 denotes pro-inflamm
T51851 309-314 NCBITaxon:10239;GO:0006260 denotes iated
T38954 315-326 GO:0006260 denotes by Ang II t
T34720 341-347 PR:000036009 denotes (AT1),
T28581 356-361 PR:000003622;G_3;PG_10 denotes imula
T52593 390-395 NCBITaxon:10239 denotes m the
T53738 461-465 PR:000001251 denotes tary
T14088 490-495 PR:000001607 denotes embra
T411 546-551 PR:000013883 denotes in 1-
T412 588-596 SP_7 denotes egulated
T413 607-620 PR:000036008 denotes K)1/ERK2 path
T414 622-627 PR:000036008 denotes ys. A
T415 769-775 PR:000036009 denotes recep
T416 797-801 PR:000001251 denotes e fo
T417 829-845 UBERON:0002053 denotes to an intermedi
T418 853-868 UBERON:0001236 denotes -9 or directly
T419 885-896 CHEBI:27584;CHEBI:27584 denotes eptidase ne
T420 922-939 CHEBI:25354;CHEBI:25354 denotes ase (PEP). RAS = 

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
218 8-12 Gene denotes ACE2 Gene:59272
219 13-19 Gene denotes Ang1-7 Gene:284
247 40-55 Gene denotes Angiotensinogen Gene:183
248 72-85 Gene denotes angiotensin I Gene:183
249 87-92 Gene denotes Ang I Gene:183
250 105-110 Gene denotes Ang I Gene:183
251 127-133 Gene denotes Ang II Gene:183
252 138-167 Gene denotes angiotensin-converting enzyme Gene:1636
253 169-172 Gene denotes ACE Gene:1636
254 197-207 Gene denotes bradykinin Gene:3827
255 295-301 Gene denotes Ang II Gene:183
256 498-502 Gene denotes ACE2 Gene:59272
257 515-527 Gene denotes Endothelin-1 Gene:1906
258 554-560 Gene denotes Ang1-7 Gene:284
259 566-610 Gene denotes extracellular signal-regulated kinase (ERK)1 Gene:5594
260 611-615 Gene denotes ERK2 Gene:5594
261 626-632 Gene denotes Ang II Gene:183
262 696-702 Gene denotes Ang1-7 Gene:284
263 707-711 Gene denotes ACE2 Gene:59272
264 780-786 Gene denotes Ang1-7 Gene:284
265 849-855 Gene denotes Ang1-9 Gene:284
266 894-904 Gene denotes neprilysin Gene:4311
267 905-925 Gene denotes prolyl endopeptidase Gene:5550
268 927-930 Gene denotes PEP Gene:5550
269 824-829 Gene denotes Ang I Gene:183
270 98-103 Gene denotes renin Gene:5972
271 365-376 Chemical denotes aldosterone MESH:D000450
272 467-478 Chemical denotes Aldosterone MESH:D000450
273 249-261 Disease denotes inflammation MESH:D007249