PMC:7161517 / 8768-9732
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T51 | 24-28 | Body_part | denotes | Axis | http://purl.org/sig/ont/fma/fma12520 |
T52 | 396-411 | Body_part | denotes | adrenal medulla | http://purl.org/sig/ont/fma/fma15633 |
T53 | 416-436 | Body_part | denotes | antidiuretic hormone | http://purl.org/sig/ont/fma/fma74646 |
T54 | 446-465 | Body_part | denotes | posterior pituitary | http://purl.org/sig/ont/fma/fma74636 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T31 | 0-3 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
T32 | 396-411 | Body_part | denotes | adrenal medulla | http://purl.obolibrary.org/obo/UBERON_0001236 |
T33 | 933-936 | Body_part | denotes | RAS | http://purl.obolibrary.org/obo/UBERON_0018229 |
T34 | 939-963 | Body_part | denotes | renin-angiotensin system | http://purl.obolibrary.org/obo/UBERON_0018229 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T47 | 249-261 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T48 | 342-345 | Disease | denotes | AT1 | http://purl.obolibrary.org/obo/MONDO_0008840 |
T49 | 456-465 | Disease | denotes | pituitary | http://purl.obolibrary.org/obo/MONDO_0021156 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T102 | 446-455 | http://purl.obolibrary.org/obo/UBERON_0001353 | denotes | posterior |
T103 | 489-497 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
T104 | 580-586 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
T105 | 894-904 | http://purl.obolibrary.org/obo/PR_000001898 | denotes | neprilysin |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T89 | 0-3 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
T90 | 40-55 | Chemical | denotes | Angiotensinogen | http://purl.obolibrary.org/obo/CHEBI_2720 |
T91 | 72-83 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T92 | 131-133 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T93 | 138-149 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T94 | 197-207 | Chemical | denotes | bradykinin | http://purl.obolibrary.org/obo/CHEBI_3165 |
T95 | 226-237 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
T96 | 299-301 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T97 | 322-324 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T98 | 365-376 | Chemical | denotes | aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834 |
T100 | 429-436 | Chemical | denotes | hormone | http://purl.obolibrary.org/obo/CHEBI_24621 |
T101 | 467-478 | Chemical | denotes | Aldosterone | http://purl.obolibrary.org/obo/CHEBI_27584 |
T102 | 515-527 | Chemical | denotes | Endothelin-1 | http://purl.obolibrary.org/obo/CHEBI_80240 |
T103 | 537-548 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
T104 | 630-632 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T105 | 872-876 | Chemical | denotes | zinc | http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185 |
T107 | 905-911 | Chemical | denotes | prolyl | http://purl.obolibrary.org/obo/CHEBI_26274|http://purl.obolibrary.org/obo/CHEBI_32874 |
T109 | 927-930 | Chemical | denotes | PEP | http://purl.obolibrary.org/obo/CHEBI_18021|http://purl.obolibrary.org/obo/CHEBI_44897 |
T111 | 933-936 | Chemical | denotes | RAS | http://purl.obolibrary.org/obo/CHEBI_63620 |
T112 | 945-956 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T30 | 29-39 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | Regulation |
T31 | 249-261 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T32 | 365-386 | http://purl.obolibrary.org/obo/GO_0035932 | denotes | aldosterone secretion |
T33 | 377-386 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T34 | 604-610 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | (ERK)1 |
T35 | 611-615 | http://purl.obolibrary.org/obo/GO_0004707 | denotes | ERK2 |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T59 | 40-104 | Sentence | denotes | Angiotensinogen is converted to angiotensin I (Ang I) via renin. |
T60 | 105-262 | Sentence | denotes | Ang I is converted to Ang II via angiotensin-converting enzyme (ACE), which also hydrolyzes bradykinin into its inactive metabolites, promoting inflammation. |
T61 | 263-466 | Sentence | denotes | The pro-inflammatory effects of Ang II are mediated by Ang II type I receptor (AT1), which stimulates aldosterone secretion from the adrenal medulla and antidiuretic hormone from the posterior pituitary. |
T62 | 467-514 | Sentence | denotes | Aldosterone decreases membrane ACE2 expression. |
T63 | 515-625 | Sentence | denotes | Endothelin-1 inhibits angiotensin 1-7 (Ang1-7) via extracellular signal-regulated kinase (ERK)1/ERK2 pathways. |
T64 | 626-779 | Sentence | denotes | Ang II, under favorable conditions (dashed line), can be converted to Ang1-7 via ACE2, whose counter regulatory effects are mediated by the Mas receptor. |
T65 | 780-932 | Sentence | denotes | Ang1-7 can also be formed via conversion of Ang I to an intermediate Ang1-9 or directly via zinc metallopeptidase neprilysin/prolyl endopeptidase (PEP). |
T66 | 933-964 | Sentence | denotes | RAS = renin-angiotensin system. |
LitCovid-PMC-OGER-BB
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T273 | 8-12 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T274 | 13-17 | PR:000036013 | denotes | Ang1 |
T275 | 20-23 | PR:000001563 | denotes | Mas |
T276 | 29-55 | GO:0065007 | denotes | Regulation Angiotensinogen |
T277 | 72-85 | PR:000036008 | denotes | angiotensin I |
T278 | 87-92 | PR:000036008 | denotes | Ang I |
T279 | 98-103 | PR:000013883 | denotes | renin |
T280 | 105-110 | PR:000036008 | denotes | Ang I |
T281 | 127-133 | PR:000036009 | denotes | Ang II |
T282 | 186-196 | MOP:0000619 | denotes | hydrolyzes |
T283 | 197-207 | CHEBI:3165;CHEBI:3165 | denotes | bradykinin |
T284 | 226-237 | CHEBI:25212;CHEBI:25212 | denotes | metabolites |
T285 | 295-301 | PR:000036009 | denotes | Ang II |
T286 | 318-324 | PR:000036009 | denotes | Ang II |
T287 | 365-376 | CHEBI:27584;CHEBI:27584 | denotes | aldosterone |
T288 | 396-411 | UBERON:0001236 | denotes | adrenal medulla |
T289 | 456-465 | UBERON:0002198 | denotes | pituitary |
T290 | 467-478 | CHEBI:27584;CHEBI:27584 | denotes | Aldosterone |
T291 | 489-497 | GO:0016020 | denotes | membrane |
T292 | 498-502 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
T293 | 503-513 | GO:0010467 | denotes | expression |
T294 | 515-525 | UBERON:0001986;PR:000006897 | denotes | Endothelin |
T295 | 525-527 | PR:000006897 | denotes | -1 |
T296 | 537-550 | PR:000036013 | denotes | angiotensin 1 |
T297 | 554-558 | PR:000036013 | denotes | Ang1 |
T298 | 566-579 | GO:0005576 | denotes | extracellular |
T299 | 587-596 | GO:0065007 | denotes | regulated |
T300 | 611-615 | PR:000000103 | denotes | ERK2 |
T301 | 626-632 | PR:000036009 | denotes | Ang II |
T302 | 696-700 | PR:000036013 | denotes | Ang1 |
T303 | 707-711 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
T304 | 780-785 | PR:000036013 | denotes | Ang1- |
T305 | 824-829 | PR:000036008 | denotes | Ang I |
T306 | 849-855 | PR:000036012 | denotes | Ang1-9 |
T307 | 894-904 | PR:000001898 | denotes | neprilysin |
T308 | 939-944 | PR:000013883 | denotes | renin |
T49835 | 31-37 | PR:000036009 | denotes | gulati |
T23691 | 52-57 | PR:000036013 | denotes | gen i |
T96566 | 61-65 | G_3;PG_10;PR:000003622 | denotes | nver |
T43762 | 124-136 | SP_10 | denotes | to Ang II vi |
T84544 | 137-147 | SP_10;UBERON:0001004 | denotes | angiotens |
T62103 | 148-168 | SP_10 | denotes | n-converting enzyme |
T45099 | 170-178 | SP_10 | denotes | CE), whi |
T96697 | 186-194 | SP_10 | denotes | hydrolyz |
T67126 | 196-200 | G_3;PG_10;PR:000003622 | denotes | bra |
T70630 | 210-219 | PG_1 | denotes | to its in |
T4074 | 245-250 | NCBITaxon:10239;GO:0035376 | denotes | ing i |
T7619 | 251-256 | GO:0035376 | denotes | flamm |
T1702 | 266-278 | GO:0044164 | denotes | pro-inflamm |
T51851 | 309-314 | NCBITaxon:10239;GO:0006260 | denotes | iated |
T38954 | 315-326 | GO:0006260 | denotes | by Ang II t |
T34720 | 341-347 | PR:000036009 | denotes | (AT1), |
T28581 | 356-361 | PR:000003622;G_3;PG_10 | denotes | imula |
T52593 | 390-395 | NCBITaxon:10239 | denotes | m the |
T53738 | 461-465 | PR:000001251 | denotes | tary |
T14088 | 490-495 | PR:000001607 | denotes | embra |
T411 | 546-551 | PR:000013883 | denotes | in 1- |
T412 | 588-596 | SP_7 | denotes | egulated |
T413 | 607-620 | PR:000036008 | denotes | K)1/ERK2 path |
T414 | 622-627 | PR:000036008 | denotes | ys. A |
T415 | 769-775 | PR:000036009 | denotes | recep |
T416 | 797-801 | PR:000001251 | denotes | e fo |
T417 | 829-845 | UBERON:0002053 | denotes | to an intermedi |
T418 | 853-868 | UBERON:0001236 | denotes | -9 or directly |
T419 | 885-896 | CHEBI:27584;CHEBI:27584 | denotes | eptidase ne |
T420 | 922-939 | CHEBI:25354;CHEBI:25354 | denotes | ase (PEP). RAS = |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
218 | 8-12 | Gene | denotes | ACE2 | Gene:59272 |
219 | 13-19 | Gene | denotes | Ang1-7 | Gene:284 |
247 | 40-55 | Gene | denotes | Angiotensinogen | Gene:183 |
248 | 72-85 | Gene | denotes | angiotensin I | Gene:183 |
249 | 87-92 | Gene | denotes | Ang I | Gene:183 |
250 | 105-110 | Gene | denotes | Ang I | Gene:183 |
251 | 127-133 | Gene | denotes | Ang II | Gene:183 |
252 | 138-167 | Gene | denotes | angiotensin-converting enzyme | Gene:1636 |
253 | 169-172 | Gene | denotes | ACE | Gene:1636 |
254 | 197-207 | Gene | denotes | bradykinin | Gene:3827 |
255 | 295-301 | Gene | denotes | Ang II | Gene:183 |
256 | 498-502 | Gene | denotes | ACE2 | Gene:59272 |
257 | 515-527 | Gene | denotes | Endothelin-1 | Gene:1906 |
258 | 554-560 | Gene | denotes | Ang1-7 | Gene:284 |
259 | 566-610 | Gene | denotes | extracellular signal-regulated kinase (ERK)1 | Gene:5594 |
260 | 611-615 | Gene | denotes | ERK2 | Gene:5594 |
261 | 626-632 | Gene | denotes | Ang II | Gene:183 |
262 | 696-702 | Gene | denotes | Ang1-7 | Gene:284 |
263 | 707-711 | Gene | denotes | ACE2 | Gene:59272 |
264 | 780-786 | Gene | denotes | Ang1-7 | Gene:284 |
265 | 849-855 | Gene | denotes | Ang1-9 | Gene:284 |
266 | 894-904 | Gene | denotes | neprilysin | Gene:4311 |
267 | 905-925 | Gene | denotes | prolyl endopeptidase | Gene:5550 |
268 | 927-930 | Gene | denotes | PEP | Gene:5550 |
269 | 824-829 | Gene | denotes | Ang I | Gene:183 |
270 | 98-103 | Gene | denotes | renin | Gene:5972 |
271 | 365-376 | Chemical | denotes | aldosterone | MESH:D000450 |
272 | 467-478 | Chemical | denotes | Aldosterone | MESH:D000450 |
273 | 249-261 | Disease | denotes | inflammation | MESH:D007249 |