Other studies highlighted the role of the ACE2/Ang1-7/Mas axis in modulating the expression of pro-inflammatory cytokines, such as TNF-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein-1, and transforming growth factor-β in cardiac and/or lung fibrosis, pulmonary hypertension, and vascular remodeling (36, 37, 38, 39, 40, 41) (Figure 1 ).