PMC:7161517 / 4687-5889
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T9 | 35-47 | Body_part | denotes | glycoprotein | http://purl.org/sig/ont/fma/fma62925 |
| T10 | 84-92 | Body_part | denotes | bronchus | http://purl.org/sig/ont/fma/fma7409 |
| T11 | 94-109 | Body_part | denotes | lung parenchyma | http://purl.org/sig/ont/fma/fma27360 |
| T12 | 111-116 | Body_part | denotes | heart | http://purl.org/sig/ont/fma/fma7088 |
| T13 | 118-129 | Body_part | denotes | endothelium | http://purl.org/sig/ont/fma/fma63916 |
| T14 | 131-138 | Body_part | denotes | kidneys | http://purl.org/sig/ont/fma/fma7203 |
| T15 | 140-148 | Body_part | denotes | duodenum | http://purl.org/sig/ont/fma/fma7206 |
| T16 | 154-169 | Body_part | denotes | small intestine | http://purl.org/sig/ont/fma/fma7200 |
| T17 | 538-551 | Body_part | denotes | phenylalanine | http://purl.org/sig/ont/fma/fma82754 |
| T18 | 773-780 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T19 | 801-811 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T20 | 834-843 | Body_part | denotes | intestine | http://purl.org/sig/ont/fma/fma7199 |
| T21 | 852-858 | Body_part | denotes | kidney | http://purl.org/sig/ont/fma/fma7203 |
| T22 | 1119-1129 | Body_part | denotes | calmodulin | http://purl.org/sig/ont/fma/fma62343 |
| T23 | 1144-1155 | Body_part | denotes | cytoplasmic | http://purl.org/sig/ont/fma/fma66835 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T16 | 84-92 | Body_part | denotes | bronchus | http://purl.obolibrary.org/obo/UBERON_0002185 |
| T17 | 94-109 | Body_part | denotes | lung parenchyma | http://purl.obolibrary.org/obo/UBERON_0008946 |
| T18 | 94-98 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T19 | 99-109 | Body_part | denotes | parenchyma | http://purl.obolibrary.org/obo/UBERON_0000353 |
| T20 | 111-129 | Body_part | denotes | heart, endothelium | http://purl.obolibrary.org/obo/UBERON_0008307 |
| T21 | 111-116 | Body_part | denotes | heart | http://purl.obolibrary.org/obo/UBERON_0000948 |
| T22 | 118-129 | Body_part | denotes | endothelium | http://purl.obolibrary.org/obo/UBERON_0001986 |
| T23 | 140-148 | Body_part | denotes | duodenum | http://purl.obolibrary.org/obo/UBERON_0002114 |
| T24 | 154-169 | Body_part | denotes | small intestine | http://purl.obolibrary.org/obo/UBERON_0002108 |
| T25 | 160-169 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T26 | 834-843 | Body_part | denotes | intestine | http://purl.obolibrary.org/obo/UBERON_0000160 |
| T27 | 852-858 | Body_part | denotes | kidney | http://purl.obolibrary.org/obo/UBERON_0002113 |
| T28 | 1156-1160 | Body_part | denotes | tail | http://purl.obolibrary.org/obo/UBERON_0002415 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T40 | 950-955 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T31 | 8-9 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T32 | 26-34 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T33 | 84-92 | http://purl.obolibrary.org/obo/UBERON_0002185 | denotes | bronchus |
| T34 | 94-98 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T35 | 94-98 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T36 | 111-116 | http://purl.obolibrary.org/obo/UBERON_0000948 | denotes | heart |
| T37 | 111-116 | http://purl.obolibrary.org/obo/UBERON_0007100 | denotes | heart |
| T38 | 111-116 | http://purl.obolibrary.org/obo/UBERON_0015228 | denotes | heart |
| T39 | 111-116 | http://www.ebi.ac.uk/efo/EFO_0000815 | denotes | heart |
| T40 | 118-129 | http://purl.obolibrary.org/obo/UBERON_0001986 | denotes | endothelium |
| T41 | 131-138 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidneys |
| T42 | 131-138 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidneys |
| T43 | 131-138 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidneys |
| T44 | 154-169 | http://purl.obolibrary.org/obo/UBERON_0002108 | denotes | small intestine |
| T45 | 184-185 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T46 | 242-243 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T47 | 329-335 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T48 | 360-363 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T49 | 364-365 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T50 | 730-731 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T51 | 732-734 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T52 | 771-772 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T53 | 834-843 | http://purl.obolibrary.org/obo/UBERON_0000160 | denotes | intestine |
| T54 | 834-843 | http://www.ebi.ac.uk/efo/EFO_0000834 | denotes | intestine |
| T55 | 852-858 | http://purl.obolibrary.org/obo/UBERON_0002113 | denotes | kidney |
| T56 | 852-858 | http://www.ebi.ac.uk/efo/EFO_0000927 | denotes | kidney |
| T57 | 852-858 | http://www.ebi.ac.uk/efo/EFO_0000929 | denotes | kidney |
| T58 | 887-888 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T59 | 1080-1081 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T60 | 1117-1118 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T61 | 1156-1160 | http://purl.obolibrary.org/obo/UBERON_0002415 | denotes | tail |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T51 | 35-47 | Chemical | denotes | glycoprotein | http://purl.obolibrary.org/obo/CHEBI_17089 |
| T52 | 284-298 | Chemical | denotes | ACE inhibitors | http://purl.obolibrary.org/obo/CHEBI_35457 |
| T53 | 288-298 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T54 | 462-464 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
| T55 | 507-518 | Chemical | denotes | angiotensin | http://purl.obolibrary.org/obo/CHEBI_48433 |
| T56 | 536-551 | Chemical | denotes | L-phenylalanine | http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997|http://purl.obolibrary.org/obo/CHEBI_58095 |
| T59 | 538-551 | Chemical | denotes | phenylalanine | http://purl.obolibrary.org/obo/CHEBI_28044 |
| T60 | 773-780 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T61 | 801-811 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T62 | 801-806 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T63 | 807-811 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T14 | 956-964 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T15 | 956-964 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T16 | 956-964 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T17 | 956-964 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T18 | 1067-1076 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 0-175 | Sentence | denotes | ACE2 is a type I integral membrane glycoprotein (15) expressed predominantly in the bronchus, lung parenchyma, heart, endothelium, kidneys, duodenum, and small intestine (16). |
| T35 | 176-304 | Sentence | denotes | ACE2 is a monocarboxypeptidase, unlike its homolog, ACE, which is a dipeptidase; ACE2 is not antagonized by ACE inhibitors (17). |
| T36 | 305-426 | Sentence | denotes | Although ACE contains 2 active catalytic domains, ACE2 has a single catalytic domain with 42% identical residues (18,19). |
| T37 | 427-557 | Sentence | denotes | The major substrate of ACE2 is Ang II, which upon C-terminus cleavage, produces angiotensin 1-7 (Ang1-7) and L-phenylalanine (20). |
| T38 | 558-678 | Sentence | denotes | Other substrates for ACE2 include Ang I, apelin-13, and dynorphin-13, which are catalyzed at much lower affinities (21). |
| T39 | 679-867 | Sentence | denotes | The non-catalytic C-terminal domain of ACE2 shares a 48% sequence homology with collectrin, a protein involved in neutral amino acid reabsorption from the intestine and the kidney (22,23). |
| T40 | 868-1097 | Sentence | denotes | In the presence of a disintegrin and metalloproteinase 17 (ADAM17), also known as tumor necrosis factor (TNF)-α−converting enzyme (TACE), ACE2 exhibits ectodomain shedding (24), which results in the formation of a soluble enzyme. |
| T41 | 1098-1202 | Sentence | denotes | ACE2 also contains a calmodulin domain on its cytoplasmic tail that influences ectodomain shedding (25). |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T7 | 950-955 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
LitCovid-PMC-OGER-BB
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T129 | 0-4 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T130 | 26-34 | GO:0016020 | denotes | membrane |
| T131 | 35-47 | CHEBI:17089;BV_11;CHEBI:17089 | denotes | glycoprotein |
| T132 | 53-62 | GO:0010467 | denotes | expressed |
| T133 | 84-92 | UBERON:0002185 | denotes | bronchus |
| T134 | 94-109 | UBERON:0008946 | denotes | lung parenchyma |
| T135 | 111-116 | UBERON:0008307 | denotes | heart |
| T136 | 118-129 | UBERON:0008307 | denotes | endothelium |
| T137 | 131-138 | UBERON:0002113 | denotes | kidneys |
| T138 | 140-148 | UBERON:0002114 | denotes | duodenum |
| T139 | 160-169 | UBERON:0002108 | denotes | intestine |
| T140 | 176-180 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T141 | 219-226 | SO:0000853 | denotes | homolog |
| T142 | 257-261 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T143 | 288-298 | CHEBI:35222;CHEBI:35222 | denotes | inhibitors |
| T144 | 346-353 | SO:0000417 | denotes | domains |
| T145 | 355-359 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T146 | 383-389 | SO:0000417 | denotes | domain |
| T147 | 450-454 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T148 | 458-464 | PR:000036009 | denotes | Ang II |
| T149 | 488-496 | MOP:0000780 | denotes | cleavage |
| T150 | 507-520 | PR:000036013 | denotes | angiotensin 1 |
| T151 | 524-529 | PR:000036013 | denotes | Ang1- |
| T152 | 579-583 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T153 | 592-597 | PR:000036008 | denotes | Ang I |
| T154 | 599-605 | PR:000004135 | denotes | apelin |
| T155 | 708-714 | SO:0000417 | denotes | domain |
| T156 | 718-722 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T157 | 745-753 | SO:0000853 | denotes | homology |
| T158 | 759-769 | PR:000016422 | denotes | collectrin |
| T159 | 834-843 | UBERON:0000160 | denotes | intestine |
| T160 | 852-858 | UBERON:0002113 | denotes | kidney |
| T161 | 927-933 | PR:000001279 | denotes | ADAM17 |
| T162 | 973-976 | PR:000000134 | denotes | TNF |
| T163 | 1006-1010 | PR:000003622;G_3;PG_10 | denotes | ACE2 |
| T164 | 1098-1102 | G_3;PG_10;PR:000003622 | denotes | ACE2 |
| T165 | 1119-1129 | PR:000004978 | denotes | calmodulin |
| T166 | 1130-1136 | SO:0000417 | denotes | domain |
| T167 | 1144-1155 | GO:0005737 | denotes | cytoplasmic |
| T28823 | 19-23 | G_3;PG_10;PR:000003622 | denotes | tegr |
| T40619 | 44-48 | PR:000000104 | denotes | ein |
| T48796 | 52-56 | PR:000009197 | denotes | exp |
| T17022 | 57-62 | PR:000002089 | denotes | essed |
| T32537 | 68-71 | PR:000045382;GO:0000187 | denotes | min |
| T9224 | 72-81 | GO:0000165 | denotes | ntly in t |
| T33582 | 150-156 | PR:000036009 | denotes | and sm |
| T84252 | 165-175 | UBERON:0002349 | denotes | tine (16). |
| T53574 | 290-294 | G_3;PG_10;PR:000003622 | denotes | hibi |
| T46680 | 295-299 | PR:000036013 | denotes | ors |
| T39192 | 313-323 | GO:0065007 | denotes | ACE conta |
| T26804 | 328-338 | GO:0010467 | denotes | active ca |
| T20064 | 378-383 | PR:000000134 | denotes | ytic |
| T15398 | 406-410 | PR:000001393 | denotes | al r |
| T8292 | 412-420 | CL:0000576;PR:000002122 | denotes | idues (1 |
| T65564 | 421-446 | PR:000002122 | denotes | ,19). The major substrate |
| T59008 | 452-480 | PR:000000046 | denotes | E2 is Ang II, which upon C-t |
| T45631 | 484-492 | UBERON:0000948 | denotes | nus clea |
| T9280 | 500-504 | UBERON:0002048 | denotes | oduc |
| T93124 | 515-524 | UBERON:0002048 | denotes | sin 1-7 ( |
| T11843 | 616-622 | G_3;PG_10;PR:000003622 | denotes | norphi |
| T96445 | 623-627 | PR:000036013 | denotes | -13, |
| T35230 | 630-633 | PR:000001563 | denotes | ich |
| T22891 | 638-664 | GO:0065007 | denotes | catalyzed at much lower af |
| T24013 | 681-694 | PR:000036008 | denotes | e non-catalyt |
| T33081 | 696-701 | PR:000036008 | denotes | C-te |
| T91867 | 707-712 | PR:000013883 | denotes | doma |
| T97324 | 714-719 | PR:000036008 | denotes | of A |
| T69975 | 736-742 | PR:000036009 | denotes | sequen |
| T54028 | 795-805 | MOP:0000619 | denotes | utral amin |
| T57012 | 806-816 | CHEBI:3165;CHEBI:3165 | denotes | acid reab |
| T52135 | 835-844 | CHEBI:25212;CHEBI:25212 | denotes | ntestine |
| T38693 | 902-910 | PR:000036009 | denotes | nd metal |
| T22665 | 927-933 | PR:000036009 | denotes | ADAM17 |
| T71601 | 973-984 | CHEBI:27584;CHEBI:27584 | denotes | TNF)-α−conv |
| T2211 | 1004-1019 | UBERON:0001236 | denotes | , ACE2 exhibits |
| T65489 | 1064-1072 | UBERON:0002198 | denotes | he forma |
| T91280 | 1074-1085 | CHEBI:27584;CHEBI:27584 | denotes | on of a sol |
| T15577 | 1096-1104 | GO:0016020 | denotes | . ACE2 a |
| T79802 | 1105-1109 | G_3;PG_10;PR:000003622 | denotes | so c |
| T96225 | 1110-1120 | GO:0010467 | denotes | ntains a c |
| T26369 | 1122-1132 | UBERON:0001986;PR:000006897 | denotes | modulin do |
| T89251 | 1132-1134 | PR:000006897 | denotes | ma |
| T83262 | 1144-1157 | PR:000036013 | denotes | cytoplasmic t |
| T85112 | 1161-1165 | PR:000036013 | denotes | that |
| T54914 | 1173-1186 | GO:0005576 | denotes | ces ectodomai |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 191 | 0-4 | Gene | denotes | ACE2 | Gene:59272 |
| 192 | 176-180 | Gene | denotes | ACE2 | Gene:59272 |
| 193 | 228-231 | Gene | denotes | ACE | Gene:1636 |
| 194 | 257-261 | Gene | denotes | ACE2 | Gene:59272 |
| 195 | 284-287 | Gene | denotes | ACE | Gene:1636 |
| 196 | 355-359 | Gene | denotes | ACE2 | Gene:59272 |
| 197 | 450-454 | Gene | denotes | ACE2 | Gene:59272 |
| 198 | 458-464 | Gene | denotes | Ang II | Gene:183 |
| 199 | 524-530 | Gene | denotes | Ang1-7 | Gene:284 |
| 200 | 579-583 | Gene | denotes | ACE2 | Gene:59272 |
| 201 | 592-597 | Gene | denotes | Ang I | Gene:183 |
| 202 | 718-722 | Gene | denotes | ACE2 | Gene:59272 |
| 203 | 759-769 | Gene | denotes | collectrin | Gene:57393 |
| 204 | 927-933 | Gene | denotes | ADAM17 | Gene:6868 |
| 205 | 950-997 | Gene | denotes | tumor necrosis factor (TNF)-α−converting enzyme | Gene:6868 |
| 206 | 999-1003 | Gene | denotes | TACE | Gene:6868 |
| 207 | 1006-1010 | Gene | denotes | ACE2 | Gene:59272 |
| 208 | 1098-1102 | Gene | denotes | ACE2 | Gene:59272 |
| 209 | 314-317 | Gene | denotes | ACE | Gene:1636 |
| 210 | 1119-1129 | Gene | denotes | calmodulin | Gene:801 |
| 211 | 536-551 | Chemical | denotes | L-phenylalanine | MESH:D010649 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32305401-24309898-55252922 | 171-173 | 24309898 | denotes | 16 |
| 32305401-15283675-55252923 | 300-302 | 15283675 | denotes | 17 |
| 32305401-1649623-55252924 | 419-421 | 1649623 | denotes | 18 |
| 32305401-2849100-55252925 | 422-424 | 2849100 | denotes | 19 |
| 32305401-11931993-55252926 | 553-555 | 11931993 | denotes | 20 |
| 32305401-11815627-55252927 | 674-676 | 11815627 | denotes | 21 |
| 32305401-18424768-55252928 | 863-865 | 18424768 | denotes | 23 |
| 32305401-15983030-55252929 | 1041-1043 | 15983030 | denotes | 24 |
| 32305401-18070603-55252930 | 1198-1200 | 18070603 | denotes | 25 |