Acknowledgment The authors thank Kristen Amodio for her contribution during discussions. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACCauthor instructions page. Listen to this manuscript's audio summary by Editor-in-Chief Dr. Valentin Fuster onJACC.org.