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PMC:7161517 / 20647-21763 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T120 0-5 Body_part denotes Serum http://purl.org/sig/ont/fma/fma63083
T121 180-186 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T122 239-244 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T123 461-467 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T124 587-591 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T125 682-688 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T126 709-715 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T127 739-746 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T128 793-795 Body_part denotes IL http://purl.org/sig/ont/fma/fma86578

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T62 0-5 Body_part denotes Serum http://purl.obolibrary.org/obo/UBERON_0001977
T63 239-244 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T64 587-591 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T65 983-986 Body_part denotes RAS http://purl.obolibrary.org/obo/UBERON_0018229

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T84 61-65 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T85 581-598 Disease denotes Acute Lung Injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T87 592-598 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T88 628-632 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T205 94-101 http://purl.obolibrary.org/obo/CLO_0009985 denotes focused
T206 180-186 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T207 239-244 http://purl.obolibrary.org/obo/UBERON_0003103 denotes organ
T208 382-383 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T209 461-467 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T210 494-495 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T211 587-591 http://purl.obolibrary.org/obo/UBERON_0002048 denotes Lung
T212 587-591 http://www.ebi.ac.uk/efo/EFO_0000934 denotes Lung
T213 682-688 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T214 709-715 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T256 28-30 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T257 201-203 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T258 482-484 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T259 540-542 Chemical denotes PK http://purl.obolibrary.org/obo/CHEBI_74792
T260 547-549 Chemical denotes PD http://purl.obolibrary.org/obo/CHEBI_74756
T261 693-695 Chemical denotes II http://purl.obolibrary.org/obo/CHEBI_74067
T262 728-738 Chemical denotes surfactant http://purl.obolibrary.org/obo/CHEBI_35195
T263 739-746 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T264 793-795 Chemical denotes IL http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072
T266 983-986 Chemical denotes RAS http://purl.obolibrary.org/obo/CHEBI_63620

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T65 771-786 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immunity

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T132 0-85 Sentence denotes Serum levels of ACE and Ang II are elevated in patients with ARDS and sepsis (55,56).
T133 86-490 Sentence denotes Studies focused on microvascular dysfunction in sepsis showed that the degree of elevation in plasma renin and Ang II were correlated with the extent of organ failure and the degree of microvascular dysfunction, especially in patients who received exogenous vasoconstrictors (56); there was also a negative correlation between re-oxygenation rates and both concentrations of plasma renin and Ang II (56).
T134 491-792 Sentence denotes In a pilot clinical trial (Safety, Tolerability, PK and PD of GSK2586881 in Patients With Acute Lung Injury; NCT01597635), patients with ARDS who were treated with rhACE2 exhibited decreased plasma Ang II and elevated plasma Ang 1-7 and surfactant protein-D, which is involved in innate immunity (57).
T135 793-955 Sentence denotes IL-6 concentrations in treated patients were also reduced, albeit statistically insignificantly, which was due to intrasubject variability and baseline imbalance.
T136 956-1116 Sentence denotes Although rhACE2 attenuated RAS mediators, infusions of the medication did not show improvement in physiological or clinical measures of ARDs in this study (57).

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T26 70-76 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T27 134-140 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T28 167-192 Phenotype denotes elevation in plasma renin http://purl.obolibrary.org/obo/HP_0000848
T29 581-598 Phenotype denotes Acute Lung Injury http://www.orpha.net/ORDO/Orphanet_178320

LitCovid-PMC-OGER-BB

Id Subject Object Predicate Lexical cue
T741 0-5 UBERON:0001977 denotes Serum
T742 24-30 PR:000036009 denotes Ang II
T743 180-186 UBERON:0001969 denotes plasma
T744 187-192 PR:000013883 denotes renin
T745 197-203 PR:000036009 denotes Ang II
T746 239-244 UBERON:0000062 denotes organ
T747 461-467 UBERON:0001969 denotes plasma
T748 468-473 PR:000013883 denotes renin
T749 478-484 PR:000036009 denotes Ang II
T750 587-591 UBERON:0002048 denotes Lung
T751 682-688 UBERON:0001969 denotes plasma
T752 689-695 PR:000036009 denotes Ang II
T753 709-715 UBERON:0001969 denotes plasma
T754 716-721 PR:000036013 denotes Ang 1
T755 728-738 CHEBI:35195;CHEBI:35195 denotes surfactant
T756 739-748 PR:000006464 denotes protein-D
T757 771-786 GO:0045087 denotes innate immunity
T758 793-797 PR:000001393 denotes IL-6
T92303 6-12 UBERON:0001969 denotes levels
T37164 13-18 PR:000036013 denotes of AC
T45720 25-35 CHEBI:35195;CHEBI:35195 denotes ng II are
T33861 36-45 PR:000006464 denotes levated i
T25070 68-84 GO:0045087 denotes d sepsis (55,56)
T51504 91-95 PR:000001393 denotes es f
T11222 494-500 SP_6;NCBITaxon:9606 denotes a pilo
T89438 501-519 UBERON:0002012 denotes clinical trial (S
T79951 568-572 G_3;PG_10;PR:000003622 denotes atie
T75956 626-633 UBERON:0000948 denotes h ARDS
T51050 682-688 UBERON:0001969 denotes plasma
T89508 716-729 CHEBI:86267;CHEBI:86267 denotes Ang 1-7 and s
T57885 793-798 UBERON:0002113 denotes IL-6
T40937 854-864 GO:0065007 denotes beit stati
T51775 939-943 G_3;PG_10;PR:000003622 denotes elin
T24590 1013-1020 PR:000009054 denotes e medic
T6576 1061-1092 PG_10;PR:000003622 denotes ogical or clinical measures of
T15507 1094-1098 G_3;PG_10;PR:000003622 denotes Ds i

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
917 16-19 Gene denotes ACE Gene:1636
918 24-30 Gene denotes Ang II Gene:183
919 187-192 Gene denotes renin Gene:5972
920 197-203 Gene denotes Ang II Gene:183
921 478-484 Gene denotes Ang II Gene:183
922 689-695 Gene denotes Ang II Gene:183
923 716-723 Gene denotes Ang 1-7 Gene:284
924 793-797 Gene denotes IL-6 Gene:3569
925 468-473 Gene denotes renin Gene:5972
926 47-55 Species denotes patients Tax:9606
927 312-320 Species denotes patients Tax:9606
928 567-575 Species denotes Patients Tax:9606
929 614-622 Species denotes patients Tax:9606
930 824-832 Species denotes patients Tax:9606
931 553-563 Chemical denotes GSK2586881
932 655-661 Chemical denotes rhACE2
933 965-971 Chemical denotes rhACE2
934 61-65 Disease denotes ARDS MESH:D012128
935 70-76 Disease denotes sepsis MESH:D018805
936 105-130 Disease denotes microvascular dysfunction MESH:D017566
937 134-140 Disease denotes sepsis MESH:D018805
938 239-252 Disease denotes organ failure MESH:D009102
939 271-296 Disease denotes microvascular dysfunction MESH:D017566
940 547-549 Disease denotes PD MESH:D010300
941 581-598 Disease denotes Acute Lung Injury MESH:D055371
942 628-632 Disease denotes ARDS MESH:D012128
943 1092-1096 Disease denotes ARDs

2_test

Id Subject Object Predicate Lexical cue
32305401-10823385-55252973 78-80 10823385 denotes 55
32305401-20175923-55252974 81-83 20175923 denotes 56
32305401-20175923-55252975 362-364 20175923 denotes 56
32305401-20175923-55252976 486-488 20175923 denotes 56
32305401-28877748-55252977 788-790 28877748 denotes 57
32305401-28877748-55252978 1112-1114 28877748 denotes 57