Glial cells—in particular mammalian astrocytes—have long been acknowledged for their key role in acquired epilepsies. Glial cell changes in metabolic regulation and neurotransmitter homeostasis for example is a key step in epileptogenesis in a number of chronic pharmacologically induced epilepsy models.4 But studies like the one by Diaz Verdugo et al now point to a much more dynamic role of glial cells in the generation and evolution of individual seizures. Astrocytes have been previously shown to respond to neuronal input, and be able to generate intracellular Ca2+-waves, which in turn can affect neuronal function and thus play an active role in information processing. This causal role in information processing has most recently also been impressively demonstrated by Mu and colleagues in zebrafish using a virtual reality setup.5 Thus, even in this most simple of vertebrate models, a dynamic coupling between glial cells and neurons is present during normal brain function, and may thus go awry during pathological states such as epileptic seizures.