Funding information This study has received funding by the National Key Research and Development Program of China (2016YFC0100300); the National Natural Science Foundation of China (Nos. 81171317, 81471631, 81771810, and 51706178), the 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China (NCET-11-0438); the China Postdoctoral Science Foundation (No. 2017M613145); and the Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University (No. XJTU1AF-CRF-2015-004).