The fever subsided, and oxygen demand decreased since day 11. The patient's condition much improved with decreased CRP and IL-6 to normal range (5.7 mg/L and < 1.5 pg/mL, respectively), and on day 18, PaO2/FiO2 increased up to 300 (Fig. 1). A chest X-ray revealed further resolution of both lung infiltrates (Fig. 2). SARS-CoV-2 was quantified by detection of the RNA-dependent RNA polymerase region of the ORF1b gene on rRT-PCR, the value of cycle threshold (Ct) changed from 24.98 on day 10 to 33.96 on day 20 after plasma infusion (Fig. 1). SARS-CoV-2 was negative after day 26. The patient underwent a tracheostomy and currently, is successfully weaned from the mechanical ventilator.