Pestiviruses are well-known animal pathogens that cause significant economic loss, infecting both domestic (e.g. pigs, cattle, sheep, and goats) and wild (e.g. wild boars and ruminants) animals (Vilcek and Nettleton 2006). Pestivirus infections may be subclinical or cause a range of clinical signs including acute diarrhea, acute hemorrhagic syndrome, acute fatal disease, as well as a wasting disease. Herein, a novel pestivirus, designated DYPV, was identified in multiple organs in one of the sick pangolins [1-Dongyang (M. javanica)] that had clear pathological changes. Phylogenetic analysis indicates that it represents a novel member of the genus Pestivirus. Although more detailed confirmatory results are required, these data suggest that DYPV-like pestiviruses may be responsible for the hemorrhagic disease observed in the pangolins.