X-ray tests revealed a large area of shadow in the left lung of pangolin 2-Lishui, suggestive of pneumonia (Supplementary Fig. S1). Due to the lack of healthy pangolin as control in this study, we used the blood biochemical values of healthy Formosan pangolins (Chin et al. 2015) as a reference. 1-Dongyang showed a significant decrease in platelet count, glucose, and cholesterol, whereas 2-Lishui exhibited a significant increase in alanine aminotransferase, aspartate aminotransferase, and amylase levels, but a decrease in total bilirubin. In addition, a lower PLT count and higher levels of alkaline phosphatases and blood urea nitrogen were observed in 4-Wucheng (Table 1 and Supplementary Table S4). Although these pangolins received careful resuscitation in the rescue station, only the pangolin 3-Ruian recovered from illness. Pangolins 1-Dongyang, 2-Lishui, and 4-Wucheng died on 3, 16, and 5 days after the admission, respectively.