ORF: open reading frame; ORF1ab: ORF encoding polyprotein; SARS-CoV-2: severe acute respiratory syndrome coronavirus. a The amino acid positions refer to those in each respective protein sequence of the Wuhan reference (GenBank accession number: MN908947), starting from the first methionine. b The two sequences characterised in this study are the ones from Italy (EPI_ISL_412973 and EPI_ISL_412974). c -: possible sequencing error.