To control the transmission of coronavirus infection many clinical activities have been reduced in most countries, including Nigeria. For people living with cancer, the diseases will continue to grow in the absence of treatment, therefore cancer may spread, develop resistance to treatments, cause multiple complications or, in some instances, death. To respond to this important area of critical need, government must constitute a multidisciplinary oncology and infectious disease team to create, review and rapidly update a clinical policy for combating COVID-19 infection during cancer care, strategise to reduce clinic visits and accelerate remote online care, empower patients and caregivers through communication using digital technology interventions and leverage on existing digital health platforms in the country. In addition, efforts should be made to support palliative and supportive care of people with advanced cancer during the outbreak by systematically identifying critical areas for consideration and development in the context of the availability of resources and expertise in resource-constrained settings such as Nigeria.