against SARS-CoV-2 infection Highlights • The COVID‐19 pandemic caused by SARS‐CoV‐2 poses a global health emergency. • Promising results suggest that chloroquine could stop the spread of SARS‐CoV‐2. • In-silico studies confirm the antiviral properties of chloroquine. • New mechanism of action of chloroquine elucidated. • Hydroxychloroquine is more potent than chloroquine. Abstract The recent emergence of the novel pathogenic SARS-coronav