• Coronavirus disease (COVID-19) represents global public health concern and WHO declares public health emergency. • The phylogenetic analysis revealed that COVID-19 is potentially a zoonotic virus. • Special attention is necessary to protect or reduce transmission in susceptible populations. • COVID-19 develop intestinal symptoms like diarrhea, while low percentage of MERS-CoV or SARS-CoV patients had diarrhea. • Identification of novel chemotherapeutic drugs for treating COVID-19 infections is urgently warranted.