The Danish Research Councils (1331-00133B); a program of excellence 2016 (Copenhagen as the next leader in precise genetic engineering CDO2016: 2016CDO04210) from the University of Copenhagen; The Danish National Research Foundation (DNRF107); Carl Emil Friis og hustru Olga Doris Friis Foundation; The Lundbeck Foundation (R219-2016-545), A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til Almene Formaal, Kirsten og Freddy Johansen Fonden, Mizutani Foundation and The Novo Nordisk Foundation. The funders had no role in preparation of the article.