•  2019-nCoV is most closely related to BatCoV RaTG13.
•  2019-nCoV belongs to subgenus Sarbecovirus of Betacoronavirus.
•  Phylogenetic profiling analysis and structural characterization of 2019-nCoV genes.
•  Functional changes in NS7b and NS8 proteins help understand 2019-nCoV.