In summary, some nonstructural proteins were conserved and others were not conserved between 2019-nCoV and SARS-CoV. By focusing on the 2019-nCoV-specific proteins, NS7b and NS8, we proposed a combination of phylogenetic profiling analysis and structural characterization of the genes that were specifically expressed in 2019-nCoV and the closely related bat coronavirus. The data provide insight for further characterization of the infective properties of this virus.