Fig. 2 Phylogenetic profiling of the annotated 2019-nCoV proteins combined with the maximum likelihood cladogram of the Orthocoronavirinae subfamily with Okavirus as the outgroup. The heatmap indicates the binary matrix of the homolog proteins of 2019-nCoV against other species in the dataset, with black and white colors as presence and absence, respectively. The bit pattern was arranged following the vertical and horizontal trees. The vertical tree is a phylogenetic profiling tree constructed from a binary matrix of the presence and absence of homolog proteins. It has two clades, indicated by blue and green bars. The horizontal tree is the cladogram of the maximum likelihood tree, as shown in Fig. 1, with a collapsed clade of 2019-nCoV. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)