RBD-Fc protein  N/A  Freund’s  I.D. or I.M.  BALB/c mice; Rabbits  Elicits SARS-CoV S/RBD-specific Abs (IgG) in mice and rabbits, neutralizing pseudotyped (rabbits: ≥ 7.3 × 104) and live (mice: 1:4 × 103; rabbits: > 1:1.5 × 104) SARS-CoV (BJ01 strain)  N/A  Protects majority (4/5) of vaccinated mice from challenge of SARS-CoV (BJ01 strain, 106 TCID50), with one mouse showing mild alveolar damage in lungs  He et al., 2004; Du et al., 2007