triSpike protein  N/A  Alum hydro  I.P. or S.C.  BALB/c mice; Hamsters  Elicits SARS-CoV S-specific mucosal and serum Abs (IgA and IgG) in mice and hamsters, blocking S-ACE2 receptor binding and neutralizing live SARS-CoV (HKU-39849 strain); induces ADE  N/A  Protects vaccinated hamsters from challenge of SARS-CoV (Urbani strain, 103 TCID50) with undetectable or reduced viral load in lungs  Kam et al., 2007; Jaume et al., 2012