Moreover, there are 4 herbal medicines available only in the severe stage. Angong Niuhuang Pill, Zhi Bao Dan, Zi Xue San, and Su He Xiang Pill played a significant role in the severe stage treatment. Angong Niuhuang Pill, Zhi Bao Dan, Zi Xue San belongs to the First Aid Three Treasures of Chinese Medicine22, which is cold in nature and is used when the patient loses consciousness due to infectious disease-induced heat. In contrast, Su He Xiang Pill is an aromatic warm-natured medicine and is used when the patient loses consciousness due to a cold pathogen. All 4 herbal medicines were prescribed in different conditions of extremely severe or critical stages based on the patients’ clinical manifestation, and they shared the same therapeutic principle to clear the orifices.