The virulence and pathogenicity of SARS-CoV-2 seem to lie between those of SARS-CoV and community-acquired HCoVs. If SARS-CoV-2 becomes more attenuated as it adapts well in humans and increases its person-to-person transmissibility as anticipated, similar strategies for prevention and control of CoVs and influenza viruses might be adopted. To reduce morbidity and mortality caused by SARS-CoV-2, vaccines could be developed. If quarantine cannot contain the spreading and if it is necessary, vaccination will provide the second opportunity to eradicate SARS-CoV-2 from humans.