Asymptomatic carriers of other HCoVs including 229E, OC43, NL63, and HKU1 have been well documented. Importantly, the detection rate of the virus in this group was lower and viral loads were much lower compared to patients with upper respiratory tract symptoms [55]. This is generally consistent with the notion that asymptomatic or presymptomatic shedding of SARS-CoV-2 might be less common than some estimates such as half to half. In this regard, epidemiological studies to determine the percentages of asymptomatic carriers and in selected large cohorts of subjects in Wuhan should help clarify the role of asymptomatic virus shedding in SARS-CoV-2 transmission. This analysis will also rule in or rule out our prediction that asymptomatic virus shedding exists but is uncommon. Since patients with non-specific and mild symptoms as well as asymptomatic carriers can go undetected easily, the chance that SARS-CoV-2 will be established in humans is increased. It will likely become either endemic in some regions or pandemic.