PMC:7102583 / 14349-15413
Annnotations
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
593 | 0-19 | Gene | denotes | NOD-like receptor 3 | Gene:114548 |
594 | 21-26 | Gene | denotes | NLRP3 | Gene:114548 |
595 | 175-180 | Gene | denotes | NLRP3 | Gene:114548 |
596 | 291-296 | Gene | denotes | NLRP3 | Gene:114548 |
597 | 353-358 | Gene | denotes | NLRP3 | Gene:216799 |
598 | 435-440 | Gene | denotes | NLRP3 | Gene:216799 |
599 | 598-603 | Gene | denotes | NLRP3 | Gene:114548 |
600 | 775-780 | Gene | denotes | NLRP3 | Gene:114548 |
601 | 1032-1037 | Gene | denotes | NLRP3 | Gene:114548 |
602 | 135-139 | Species | denotes | CoVs | Tax:11118 |
603 | 321-326 | Species | denotes | mouse | Tax:10090 |
604 | 666-683 | Species | denotes | influenza A virus | Tax:11320 |
605 | 529-538 | Chemical | denotes | melatonin | MESH:D008550 |
606 | 751-760 | Chemical | denotes | melatonin | MESH:D008550 |
607 | 864-870 | Chemical | denotes | oxygen | MESH:D010100 |
608 | 920-929 | Chemical | denotes | melatonin | MESH:D008550 |
609 | 86-100 | Disease | denotes | lung infection | MESH:D012141 |
610 | 207-219 | Disease | denotes | inflammation | MESH:D007249 |
611 | 381-390 | Disease | denotes | infection | MESH:D007239 |
612 | 401-410 | Disease | denotes | mortality | MESH:D003643 |
613 | 456-465 | Disease | denotes | infection | MESH:D007239 |
614 | 546-550 | Disease | denotes | ARDS | MESH:D012128 |
615 | 556-568 | Disease | denotes | inflammation | MESH:D007249 |
616 | 621-634 | Disease | denotes | lung diseases | MESH:D008171 |
617 | 645-654 | Disease | denotes | infection | MESH:D007239 |
618 | 818-829 | Disease | denotes | lung injury | MESH:D055370 |
619 | 831-859 | Disease | denotes | allergic airway inflammation | MESH:D007249 |
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T154 | 86-90 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T155 | 304-308 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T156 | 529-538 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T157 | 621-625 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T158 | 751-760 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T159 | 818-822 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T160 | 920-929 | Body_part | denotes | melatonin | http://purl.org/sig/ont/fma/fma74644 |
T161 | 958-969 | Body_part | denotes | macrophages | http://purl.org/sig/ont/fma/fma63261 |
T162 | 974-985 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
T163 | 995-999 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T33 | 86-90 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T34 | 304-308 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T35 | 621-625 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T36 | 818-822 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T37 | 995-999 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid_AGAC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
p51326s19 | 195-202 | PosReg | denotes | amplify |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T153 | 0-3 | Disease | denotes | NOD | http://purl.obolibrary.org/obo/MONDO_0007435 |
T154 | 91-100 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T155 | 207-219 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T156 | 381-390 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T157 | 456-465 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T158 | 542-545 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
T159 | 546-550 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
T160 | 556-568 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T161 | 621-634 | Disease | denotes | lung diseases | http://purl.obolibrary.org/obo/MONDO_0005275 |
T162 | 645-654 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
T163 | 666-675 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
T164 | 823-829 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
T165 | 831-839 | Disease | denotes | allergic | http://purl.obolibrary.org/obo/MONDO_0004980 |
T166 | 847-859 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T167 | 879-882 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
T168 | 899-902 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
T169 | 1003-1006 | Disease | denotes | ALI | http://purl.obolibrary.org/obo/MONDO_0006502 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T181 | 86-90 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T182 | 86-90 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T183 | 126-127 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T184 | 128-133 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T185 | 140-143 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T186 | 157-163 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
T187 | 181-191 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
T188 | 239-240 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T189 | 304-308 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T190 | 304-308 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T191 | 319-320 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T192 | 321-326 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
T193 | 478-479 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T194 | 621-625 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T195 | 621-625 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T196 | 676-677 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T197 | 678-683 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T198 | 695-700 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
T199 | 706-714 | http://purl.obolibrary.org/obo/NCBITaxon_2 | denotes | bacteria |
T200 | 723-725 | http://purl.obolibrary.org/obo/CLO_0001407 | denotes | 52 |
T201 | 781-784 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
T202 | 818-822 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T203 | 818-822 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T204 | 840-846 | http://purl.obolibrary.org/obo/UBERON_0001005 | denotes | airway |
T205 | 995-999 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T206 | 995-999 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T146 | 529-538 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T147 | 751-760 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
T148 | 864-870 | Chemical | denotes | oxygen | http://purl.obolibrary.org/obo/CHEBI_25805 |
T149 | 887-890 | Chemical | denotes | LPS | http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981 |
T152 | 920-929 | Chemical | denotes | melatonin | http://purl.obolibrary.org/obo/CHEBI_16796 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T67 | 56-78 | http://purl.obolibrary.org/obo/GO_0045087 | denotes | innate immune response |
T68 | 63-78 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
T69 | 207-219 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T70 | 556-568 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T71 | 847-859 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T99 | 0-101 | Sentence | denotes | NOD-like receptor 3 (NLRP3) inflammasome is part of the innate immune response during lung infection. |
T100 | 102-220 | Sentence | denotes | The pathogen, including a virus (CoVs has not yet been tested), triggers NLRP3 activation to amplify the inflammation. |
T101 | 221-309 | Sentence | denotes | There is probably a balance of the protective and damaging actions of NLRP3 in the lung. |
T102 | 310-503 | Sentence | denotes | Thus, in a mouse experiment, inhibition of NLRP3 in the early phase of infection increased mortality, whereas suppression of NLRP3 at the peak of infection allowed for a protective effect [51]. |
T103 | 504-584 | Sentence | denotes | This supports the use of melatonin in ALI/ARDS when inflammation is most severe. |
T104 | 585-734 | Sentence | denotes | Inflammasome NLRP3 is correlated to lung diseases caused by infection, including influenza A virus, syncytial virus, and bacteria [[51], [52], [53]]. |
T105 | 735-1064 | Sentence | denotes | The efficacy of melatonin in regulating NLRP3 has been proven in radiation-induced lung injury, allergic airway inflammation and oxygen-induced ALI and LPS-induced ALI models, in which melatonin reduced the infiltration of macrophages and neutrophils into the lung in ALI due to the inhibition of NLRP3 inflammasome [4,28,54,55]. |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T70 | 542-545 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
T71 | 621-634 | Phenotype | denotes | lung diseases | http://purl.obolibrary.org/obo/HP_0002088 |
T72 | 879-882 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
T73 | 899-902 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
T74 | 1003-1006 | Phenotype | denotes | ALI | http://www.orpha.net/ORDO/Orphanet_178320 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
32217117-27283237-66453507 | 499-501 | 27283237 | denotes | 51 |
32217117-27283237-66453508 | 717-719 | 27283237 | denotes | 51 |
32217117-32047436-66453509 | 723-725 | 32047436 | denotes | 52 |
32217117-17803352-66453510 | 729-731 | 17803352 | denotes | 53 |
32217117-25491480-66453511 | 1054-1056 | 25491480 | denotes | 28 |
32217117-31738882-66453512 | 1057-1059 | 31738882 | denotes | 54 |
32217117-26888116-66453513 | 1060-1062 | 26888116 | denotes | 55 |