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PMC:7102583 / 14349-15413 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
593 0-19 Gene denotes NOD-like receptor 3 Gene:114548
594 21-26 Gene denotes NLRP3 Gene:114548
595 175-180 Gene denotes NLRP3 Gene:114548
596 291-296 Gene denotes NLRP3 Gene:114548
597 353-358 Gene denotes NLRP3 Gene:216799
598 435-440 Gene denotes NLRP3 Gene:216799
599 598-603 Gene denotes NLRP3 Gene:114548
600 775-780 Gene denotes NLRP3 Gene:114548
601 1032-1037 Gene denotes NLRP3 Gene:114548
602 135-139 Species denotes CoVs Tax:11118
603 321-326 Species denotes mouse Tax:10090
604 666-683 Species denotes influenza A virus Tax:11320
605 529-538 Chemical denotes melatonin MESH:D008550
606 751-760 Chemical denotes melatonin MESH:D008550
607 864-870 Chemical denotes oxygen MESH:D010100
608 920-929 Chemical denotes melatonin MESH:D008550
609 86-100 Disease denotes lung infection MESH:D012141
610 207-219 Disease denotes inflammation MESH:D007249
611 381-390 Disease denotes infection MESH:D007239
612 401-410 Disease denotes mortality MESH:D003643
613 456-465 Disease denotes infection MESH:D007239
614 546-550 Disease denotes ARDS MESH:D012128
615 556-568 Disease denotes inflammation MESH:D007249
616 621-634 Disease denotes lung diseases MESH:D008171
617 645-654 Disease denotes infection MESH:D007239
618 818-829 Disease denotes lung injury MESH:D055370
619 831-859 Disease denotes allergic airway inflammation MESH:D007249

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T154 86-90 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T155 304-308 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T156 529-538 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T157 621-625 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T158 751-760 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T159 818-822 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T160 920-929 Body_part denotes melatonin http://purl.org/sig/ont/fma/fma74644
T161 958-969 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T162 974-985 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T163 995-999 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T33 86-90 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T34 304-308 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T35 621-625 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T36 818-822 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T37 995-999 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid_AGAC

Id Subject Object Predicate Lexical cue
p51326s19 195-202 PosReg denotes amplify

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T153 0-3 Disease denotes NOD http://purl.obolibrary.org/obo/MONDO_0007435
T154 91-100 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T155 207-219 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T156 381-390 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T157 456-465 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T158 542-545 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T159 546-550 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T160 556-568 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T161 621-634 Disease denotes lung diseases http://purl.obolibrary.org/obo/MONDO_0005275
T162 645-654 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T163 666-675 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T164 823-829 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T165 831-839 Disease denotes allergic http://purl.obolibrary.org/obo/MONDO_0004980
T166 847-859 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T167 879-882 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T168 899-902 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T169 1003-1006 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T181 86-90 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T182 86-90 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T183 126-127 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T184 128-133 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T185 140-143 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T186 157-163 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T187 181-191 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T188 239-240 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T189 304-308 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T190 304-308 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T191 319-320 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T192 321-326 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T193 478-479 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T194 621-625 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T195 621-625 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T196 676-677 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T197 678-683 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T198 695-700 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T199 706-714 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T200 723-725 http://purl.obolibrary.org/obo/CLO_0001407 denotes 52
T201 781-784 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T202 818-822 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T203 818-822 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T204 840-846 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway
T205 995-999 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T206 995-999 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T146 529-538 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T147 751-760 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796
T148 864-870 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T149 887-890 Chemical denotes LPS http://purl.obolibrary.org/obo/CHEBI_16412|http://purl.obolibrary.org/obo/CHEBI_52603|http://purl.obolibrary.org/obo/CHEBI_89981
T152 920-929 Chemical denotes melatonin http://purl.obolibrary.org/obo/CHEBI_16796

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T67 56-78 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T68 63-78 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T69 207-219 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T70 556-568 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T71 847-859 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T99 0-101 Sentence denotes NOD-like receptor 3 (NLRP3) inflammasome is part of the innate immune response during lung infection.
T100 102-220 Sentence denotes The pathogen, including a virus (CoVs has not yet been tested), triggers NLRP3 activation to amplify the inflammation.
T101 221-309 Sentence denotes There is probably a balance of the protective and damaging actions of NLRP3 in the lung.
T102 310-503 Sentence denotes Thus, in a mouse experiment, inhibition of NLRP3 in the early phase of infection increased mortality, whereas suppression of NLRP3 at the peak of infection allowed for a protective effect [51].
T103 504-584 Sentence denotes This supports the use of melatonin in ALI/ARDS when inflammation is most severe.
T104 585-734 Sentence denotes Inflammasome NLRP3 is correlated to lung diseases caused by infection, including influenza A virus, syncytial virus, and bacteria [[51], [52], [53]].
T105 735-1064 Sentence denotes The efficacy of melatonin in regulating NLRP3 has been proven in radiation-induced lung injury, allergic airway inflammation and oxygen-induced ALI and LPS-induced ALI models, in which melatonin reduced the infiltration of macrophages and neutrophils into the lung in ALI due to the inhibition of NLRP3 inflammasome [4,28,54,55].

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T70 542-545 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T71 621-634 Phenotype denotes lung diseases http://purl.obolibrary.org/obo/HP_0002088
T72 879-882 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T73 899-902 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T74 1003-1006 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320

2_test

Id Subject Object Predicate Lexical cue
32217117-27283237-66453507 499-501 27283237 denotes 51
32217117-27283237-66453508 717-719 27283237 denotes 51
32217117-32047436-66453509 723-725 32047436 denotes 52
32217117-17803352-66453510 729-731 17803352 denotes 53
32217117-25491480-66453511 1054-1056 25491480 denotes 28
32217117-31738882-66453512 1057-1059 31738882 denotes 54
32217117-26888116-66453513 1060-1062 26888116 denotes 55